Dendritic Cell marker Antibody (1F119): sc-52661

Dendritic Cell marker Antibody (1F119) is a mouse monoclonal IgM antibody that detects the Dendritic Cell marker protein of mouse and rat origin by immunofluorescence (IF) and flow cytometry (FCM). Dendritic Cell marker (1F119) antibody is available in both non-conjugated and various conjugated forms, including fluorescein isothiocyanate (FITC), providing flexibility for different experimental needs. Dendritic cells play a pivotal role in the immune system as potent antigen-presenting cells, essential for the initiation of T cell responses, antigen capture, and migration, which are crucial for effective cell-mediated immunity. These cells are strategically located in various non-lymphoid tissues, where they actively take up and process antigens. Upon stimulation, dendritic cells undergo maturation and migrate to secondary lymphoid tissues, where they present processed antigens on their surface in conjunction with major histocompatibility complex (MHC) molecules. This interaction is vital for the activation of T cells, thereby influencing the adaptive immune response. The ability of dendritic cells to interact with specific proteins, such as CD40 and CD80, further enhances their function in T cell activation and differentiation, making Dendritic Cell marker (1F119) monoclonal antibody an invaluable tool for researchers studying immune responses and dendritic cell biology.

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Dendritic Cell marker Antibody (1F119) References:

1. Dendritic cells and the control of immunity: enhancing the efficiency of antigen presentation.  |  Steinman, RM. 2001. Mt Sinai J Med. 68: 160-6. PMID: 11373688
2. Differentiation of immunostimulatory stem-cell- and monocyte-derived dendritic cells involves maturation of intracellular compartments responsible for antigen presentation and secretion.  |  Bykovskaia, SN., et al. 2002. Stem Cells. 20: 380-93. PMID: 12351809
3. Dendritic cells: translating innate to adaptive immunity.  |  Steinman, RM. and Hemmi, H. 2006. Curr Top Microbiol Immunol. 311: 17-58. PMID: 17048704
4. The dendritic cell system and its role in immunogenicity.  |  Steinman, RM. 1991. Annu Rev Immunol. 9: 271-96. PMID: 1910679
5. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.  |  Sallusto, F., et al. 1995. J Exp Med. 182: 389-400. PMID: 7629501
6. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.  |  Sallusto, F. and Lanzavecchia, A. 1994. J Exp Med. 179: 1109-18. PMID: 8145033
7. Origin, maturation and antigen presenting function of dendritic cells.  |  Cella, M., et al. 1997. Curr Opin Immunol. 9: 10-6. PMID: 9039784
8. Dendritic type, accessory cells within the mammalian thymic microenvironment. Antigen presentation in the dendritic neuro-endocrine-immune cellular network.  |  Bodey, B., et al. 1997. In Vivo. 11: 351-70. PMID: 9292303
9. Dendritic cells and the control of immunity.  |  Banchereau, J. and Steinman, RM. 1998. Nature. 392: 245-52. PMID: 9521319

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dendritic Cell marker Antibody (1F119) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Dendritic Cell marker Antibody (1F119) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dendritic Cell marker Antibody (1F119) Specifications

Alternate Product Name: Dendritic Cell marker

Product Clone Name: 1F119

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: Dendritic Cell marker

Epitope Species: rat

Product Reactivity/Detection: Dendritic Cells

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM

Vialing Information: Each vial contains 100 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Dendritic Cell marker Antibody (1F119): FITC: Fluoroscein