ΔN p73 Antibody (38C674): sc-56086
- ΔN p73 Antibody (38C674) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against amino acids 2-13 of ΔN p73 of human origin
- recommended for detection of ΔN p73 of mouse, rat and human origin by WB; non cross-reactive with full-length p73
- See p73 (E-4): sc-17823 for ΔN p73 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ΔN p73 Antibody (38C674). This work is in progress.
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ΔN p73 Antibody (38C674) is a mouse monoclonal IgG1 antibody designed to detect the ΔN p73 isoform, also known as Np73, in human, mouse, and rat samples using western blotting (WB). ΔN p73 monoclonal antibody (38C674) targets an epitope within amino acids 2-13 of the ΔN p73 protein, ensuring selective recognition without cross-reactivity with the full-length p73 isoform. ΔN p73 is an N-terminally truncated variant of the TP73 protein, a member of the p53 family of transcription factors that play a critical role in regulating cell cycle progression and apoptosis. Unlike the full-length TAp73, ΔN p73 lacks the transactivation domain and acts as a dominant-negative inhibitor of both wild-type p53 and TAp73, interfering with tumor suppressor functions. This inhibitory action is significant in cancer, as ΔN p73 is frequently overexpressed in various malignancies, contributing to tumor growth and drug resistance by preventing apoptosis and promoting cell survival. Within the cell, ΔN p73 is primarily localized in the nucleus, where ΔN p73 can interact with other transcription factors and regulatory proteins to modulate gene expression crucial for cell fate decisions. Understanding the localization and function of ΔN p73 is essential for elucidating its role in oncogenesis and for developing targeted cancer therapies. ΔN p73 (38C674) monoclonal antibody is an invaluable tool for researchers studying the molecular mechanisms of cancer progression and the intricate balance between pro- and anti-apoptotic signals mediated by p73 isoforms. By facilitating accurate detection and quantification of ΔN p73, anti-ΔN p73 antibody (38C674) supports advancements in cancer diagnostics and the development of novel therapeutic strategies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ΔN p73 Antibody (38C674) | sc-56086 | 100 µg/ml | $322.00 |