DDX43 Antibody (LW-M1): sc-134311

DDX43 Antibody (LW-M1) is a mouse monoclonal IgG2a kappa light chain antibody that detects DDX43 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-DDX43 antibody (LW-M1) is available as a non-conjugated monoclonal isotype antibody. DDX43, also known as CT13 or HAGE, is a 648 amino acid protein that plays a crucial role in various cellular processes, particularly in RNA metabolism. DDX43 contains one KH domain, one helicase C-terminal domain, and one helicase ATP-binding domain, which are essential for its function as an ATP-dependent RNA helicase. DDX43 is predominantly expressed in the testis and is found at elevated levels in several tumors, suggesting involvement in tumorigenesis and metastasis. DDX43 presence in cancer cells may indicate potential as a biomarker for tumor progression and a target for therapeutic intervention. Understanding DDX43 function is vital, as DDX43 may influence RNA secondary structure modifications and the assembly of ribosomes and spliceosomes, processes that are critical for proper gene expression and cellular function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

DDX43 Antibody (LW-M1) References:

1. Identification on a human sarcoma of two new genes with tumor-specific expression.  |  Martelange, V., et al. 2000. Cancer Res. 60: 3848-55. PMID: 10919659
2. The human DDX and DHX gene families of putative RNA helicases.  |  Abdelhaleem, M., et al. 2003. Genomics. 81: 618-22. PMID: 12782131
3. Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands.  |  Nagel, H., et al. 2003. Mol Pathol. 56: 226-31. PMID: 12890744
4. The newly discovered Q motif of DEAD-box RNA helicases regulates RNA-binding and helicase activity.  |  Cordin, O., et al. 2004. EMBO J. 23: 2478-87. PMID: 15201868
5. D-E-A-D protein family of putative RNA helicases.  |  Schmid, SR. and Linder, P. 1992. Mol Microbiol. 6: 283-91. PMID: 1552844
6. Dead-box proteins: a family affair--active and passive players in RNP-remodeling.  |  Linder, P. 2006. Nucleic Acids Res. 34: 4168-80. PMID: 16936318
7. Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia.  |  Roman-Gomez, J., et al. 2007. Haematologica. 92: 153-62. PMID: 17296563
8. HAGE, a cancer/testis antigen with potential for melanoma immunotherapy: identification of several MHC class I/II HAGE-derived immunogenic peptides.  |  Mathieu, MG., et al. 2007. Cancer Immunol Immunother. 56: 1885-95. PMID: 17487488