DDX17 Antibody (F-4): sc-376396

DDX17 Antibody (F-4) is a mouse monoclonal IgG1 antibody that detects DDX17 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DDX17, also known as p72, is a member of the DEAD box protein family, characterized by the conserved motif Asp-Glu-Ala-Asp, which plays a crucial role as a putative RNA helicase involved in various cellular processes, including translation initiation and RNA splicing. DDX17′s ability to modulate RNA secondary structure is vital for the proper assembly of ribosomes and spliceosomes, which are essential for protein synthesis and gene expression regulation. DDX17 is highly homologous to DDX5 (p68) and has been shown to act as a transcriptional co-regulator for key transcription factors such as estrogen receptor alpha, p53, MyoD, and Runx2, thereby influencing cellular growth and differentiation. Notably, impairment of DDX17 function has been linked to developmental disorders, including Down Syndrome, highlighting DDX17′s importance in early brain development. Anti-DDX17 antibody (F-4) is an invaluable tool for researchers investigating the roles of RNA helicases in cellular processes and their implications in various diseases.

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DDX17 Antibody (F-4) References:

1. RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation.  |  Dardenne, E., et al. 2014. Cell Rep. 7: 1900-13. PMID: 24910439
2. Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense.  |  Moy, RH., et al. 2014. Cell. 158: 764-777. PMID: 25126784
3. DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer.  |  Alqahtani, H., et al. 2016. Cell Signal. 28: 42-50. PMID: 26569340
4. The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells.  |  Connerty, P., et al. 2016. Biochim Biophys Acta. 1859: 1299-305. PMID: 27478153
5. DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of β-catenin.  |  Li, K., et al. 2017. Cancer Lett. 400: 194-202. PMID: 28259822
6. The RNA helicase DDX17 controls the transcriptional activity of REST and the expression of proneural microRNAs in neuronal differentiation.  |  Lambert, MP., et al. 2018. Nucleic Acids Res. 46: 7686-7700. PMID: 29931089
7. Regulation of miRNA Biogenesis and Histone Modification by K63-Polyubiquitinated DDX17 Controls Cancer Stem-like Features.  |  Kao, SH., et al. 2019. Cancer Res. 79: 2549-2563. PMID: 30877109
8. Long noncoding RNA SNHG20 promotes prostate cancer progression via upregulating DDX17.  |  Wu, XC., et al. 2021. Arch Med Sci. 17: 1752-1765. PMID: 34900057
9. The RNA helicases DDX5 and DDX17 facilitate neural differentiation of human pluripotent stem cells NTERA2.  |  Suthapot, P., et al. 2022. Life Sci. 291: 120298. PMID: 35007564
10. THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate.  |  Polenkowski, M., et al. 2023. iScience. 26: 105784. PMID: 36590164

The preferred DDX17 antibody is DDX17 Antibody (H-7): sc-398168.