Dcun1D1/2 Antibody (A-11): sc-398218
- Dcun1D1/2 Antibody (A-11) is a mouse monoclonal IgG2a κ Dcun1D1/2 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 71-233 mapping within an internal region of Dcun1D1 of human origin
- Dcun1D1/2 Antibody (A-11) is recommended for detection of Dcun1D1 and Dcun1D2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-Dcun1D1/2 Antibody (A-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Dcun1D1/2 Antibody (A-11) for WB applications. This reagent is now offered in a bundle with Dcun1D1/2 Antibody (A-11) (see ordering information below).
Dcun1D1/2 Antibody (A-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects Dcun1D1/2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Dcun1D1/2 antibody (A-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dcun1D1, also known as Defective in cullin neddylation protein 1-like protein 1, plays a crucial role in regulating the hedgehog signaling pathway, which is essential for cellular development, tissue maintenance, and regeneration. Dcun1D1 is primarily located in the cytoplasm, where Dcun1D1 interacts with cullin proteins to facilitate neddylation, a post-translational modification vital for proper functioning of the ubiquitin-proteasome system. Dysregulation of this process can lead to aberrant protein degradation and has been implicated in various cancers, including non-small cell lung cancer, where Dcun1D1 overexpression is associated with invasive tumor progression and poor patient outcomes. Co-expression of Dcun1D1 with vascular endothelial growth factor-A highlights Dcun1D1′s role in promoting angiogenesis, making Dcun1D1 a significant target for understanding tumor biology and potential therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Dcun1D1/2 Antibody (A-11) References:
- The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue. | Estilo, CL., et al. 2003. Clin Cancer Res. 9: 2300-6. PMID: 12796399
- Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A. | Talbot, SG., et al. 2004. Ann Surg Oncol. 11: 530-4. PMID: 15123463
- The Hedgehog response network: sensors, switches, and routers. | Lum, L. and Beachy, PA. 2004. Science. 304: 1755-9. PMID: 15205520
- SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma. | Sarkaria, IS., et al. 2004. Ann Thorac Surg. 78: 1734-41. PMID: 15511464
- Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors. | Jacques, C., et al. 2005. J Clin Endocrinol Metab. 90: 2314-20. PMID: 15623817
- Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas. | Sarkaria, IS., et al. 2004. Surgery. 136: 1122-8. PMID: 15657565
- The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. | Kurz, T., et al. 2005. Nature. 435: 1257-61. PMID: 15988528
- Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas. | Sarkaria, I., et al. 2006. Cancer Res. 66: 9437-44. PMID: 17018598
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dcun1D1/2 Antibody (A-11) | sc-398218 | 200 µg/ml | $322.00 | |||
Dcun1D1/2 Antibody (A-11): m-IgG Fc BP-HRP Bundle | sc-552118 | 200 µg Ab; 10 µg BP | $361.00 | |||
Dcun1D1/2 Antibody (A-11) AC | sc-398218 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Dcun1D1/2 Antibody (A-11) HRP | sc-398218 HRP | 200 µg/ml | $322.00 | |||
Dcun1D1/2 Antibody (A-11) FITC | sc-398218 FITC | 200 µg/ml | $336.00 | |||
Dcun1D1/2 Antibody (A-11) PE | sc-398218 PE | 200 µg/ml | $349.00 | |||
Dcun1D1/2 Antibody (A-11) Alexa Fluor® 488 | sc-398218 AF488 | 200 µg/ml | $364.00 | |||
Dcun1D1/2 Antibody (A-11) Alexa Fluor® 546 | sc-398218 AF546 | 200 µg/ml | $364.00 | |||
Dcun1D1/2 Antibody (A-11) Alexa Fluor® 594 | sc-398218 AF594 | 200 µg/ml | $364.00 | |||
Dcun1D1/2 Antibody (A-11) Alexa Fluor® 647 | sc-398218 AF647 | 200 µg/ml | $364.00 | |||
Dcun1D1/2 Antibody (A-11) Alexa Fluor® 680 | sc-398218 AF680 | 200 µg/ml | $364.00 | |||
Dcun1D1/2 Antibody (A-11) Alexa Fluor® 790 | sc-398218 AF790 | 200 µg/ml | $364.00 |