dcTRAILR2 Antibody (Lucy-1): sc-57078

dcTRAILR2 Antibody (Lucy-1) is a rat monoclonal IgG2a antibody that detects dcTRAILR2 protein of mouse origin by flow cytometry (FCM). Anti-dcTRAILR2 antibody (Lucy-1) is available as a non-conjugated monoclonal isotype antibody. dcTRAILR2 plays a crucial role in the regulation of apoptosis, acting as a decoy receptor for the cytotoxic ligand TNFSF10/TRAIL. Unlike TRAILR1 and TRAILR2, dcTRAILR2 lacks a cytoplasmic death domain, preventing initiation of apoptotic signaling or activation of the NFκB pathway. This unique characteristic allows dcTRAILR2 to protect cells from TRAIL-mediated apoptosis, potentially through competitive inhibition of ligand binding. Understanding dcTRAILR2 function is vital, as dcTRAILR2 highlights the balance between cell survival and death, particularly in cancer biology where tumor cells often exploit these pathways to evade apoptosis. Anti-dcTRAILR2 antibody (Lucy-1) enables researchers to gain insights into apoptosis regulation mechanisms and potential therapeutic implications for cancer treatment.

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dcTRAILR2 Antibody (Lucy-1) References:

1. Murine TRAIL (TNF-related apoptosis inducing ligand) expression induced by T cell activation is blocked by rapamycin, cyclosporin A, and inhibitors of phosphatidylinositol 3-kinase, protein kinase C, and protein tyrosine kinases: evidence for TRAIL induction via the T cell receptor signaling pathway.  |  Musgrave, BL., et al. 1999. Exp Cell Res. 252: 96-103. PMID: 10502402
2. Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers.  |  Shin, MS., et al. 2001. Cancer Res. 61: 4942-6. PMID: 11431320
3. Functional expression of TRAIL and TRAIL-R2 during human megakaryocytic development.  |  Melloni, E., et al. 2005. J Cell Physiol. 204: 975-82. PMID: 15828026
4. Upregulation of TRAIL-R2 is not involved in HDACi mediated sensitization to TRAIL-induced apoptosis.  |  Inoue, S., et al. 2006. Cell Death Differ. 13: 2160-2. PMID: 16729023
5. Identification and characterization of a new member of the TNF family that induces apoptosis.  |  Wiley, SR., et al. 1995. Immunity. 3: 673-82. PMID: 8777713
6. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.  |  Walczak, H., et al. 1997. EMBO J. 16: 5386-97. PMID: 9311998

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-dcTRAILR2 Antibody (Lucy-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-dcTRAILR2 Antibody (Lucy-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

dcTRAILR2 Antibody (Lucy-1) Specifications

Alternate Product Name: dcTRAILR2

Product Clone Name: Lucy-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids: 1-170

Epitope Target: dcTRAILR2

Epitope Species: mouse

Product Reactivity/Detection: dcTRAILR2

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: FCM

Vialing Information: Each vial contains 50 µg IgG_2a in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for dcTRAILR2 Antibody (Lucy-1): N/A