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DcR2 Antibody (B-P30): sc-65310

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Datasheets
  • DcR2 Antibody (B-P30) is a mouse monoclonal IgG1 κ DcR2 antibody, cited in 2 publications, provided at 100 µg/ml
  • raised against recombinant TRAIL R4/Fc chimera of human origin
  • recommended for detection of DcR2 of human origin by WB and IP
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DcR2 Antibody (B-P30). This work is in progress.

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DcR2 Antibody (B-P30) is a mouse monoclonal IgG1 kappa light chain antibody that detects DcR2 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-DcR2 antibody (B-P30) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. DcR2 (B-P30) antibody recognizes decoy receptor 2, which plays a critical role in modulating apoptosis by acting as a decoy for ligands that typically bind to death receptors, thereby inhibiting apoptotic signaling pathways. This function is particularly significant in cancer, where decoy receptor 2 can contribute to tumor cell survival by preventing apoptosis in response to pro-apoptotic signals. Understanding DcR2 interactions with ligands, such as TRAIL (TNF-related apoptosis-inducing ligand), is essential for elucidating its role in tumorigenesis and developing potential therapeutic strategies. DcR2 (B-P30) monoclonal antibody enables valuable insights into apoptosis mechanisms and potential cancer treatment pathways.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

DcR2 Antibody (B-P30) References:

  1. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis.  |  Yu, KY., et al. 1999. J Biol Chem. 274: 13733-6. PMID: 10318773
  2. Urinary DcR2 is a novel biomarker for tubulointerstitial injury in patients with diabetic nephropathy.  |  Chen, J., et al. 2017. Am J Physiol Renal Physiol. 313: F273-F281. PMID: 28356293
  3. The Fas death factor.  |  Nagata, S. and Golstein, P. 1995. Science. 267: 1449-56. PMID: 7533326
  4. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death.  |  Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429
  5. A novel domain within the 55 kd TNF receptor signals cell death.  |  Tartaglia, LA., et al. 1993. Cell. 74: 845-53. PMID: 8397073
  6. A death-domain-containing receptor that mediates apoptosis.  |  Kitson, J., et al. 1996. Nature. 384: 372-5. PMID: 8934525
  7. The receptor for the cytotoxic ligand TRAIL.  |  Pan, G., et al. 1997. Science. 276: 111-3. PMID: 9082980
  8. An antagonist decoy receptor and a death domain-containing receptor for TRAIL.  |  Pan, G., et al. 1997. Science. 277: 815-8. PMID: 9242610
  9. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.  |  Sheridan, JP., et al. 1997. Science. 277: 818-21. PMID: 9242611
  10. A novel receptor for Apo2L/TRAIL contains a truncated death domain.  |  Marsters, SA., et al. 1997. Curr Biol. 7: 1003-6. PMID: 9382840
  11. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling.  |  Pan, G., et al. 1998. FEBS Lett. 424: 41-5. PMID: 9537512
  12. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor.  |  Pan, G., et al. 1998. FEBS Lett. 431: 351-6. PMID: 9714541

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DcR2 Antibody (B-P30)

sc-65310
100 µg/ml
$316.00

I am using DcR2 (B-P30): sc-65310 antibody for immunoprecipitation, how much antibody should I use?

Asked by: TinTin
Thank you for your question. We recommend using 1–10 µl (i.e., 0.2–2 µg) of antibody with 1 ml of cell lysate. However, optimal antibody concentration should be determined by titration. Please find our full immunoprecipitation protocol here: https://www.scbt.com/scbt/resources/protocols/immunoprecipitation-western-blots
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Good for Western BlotAntibody has been used for western blot in published research. -SCBT QC
Date published: 2023-09-14
Rated 4 out of 5 by from This antibody was used in a publication forThis antibody was used in a publication for WB on MCF-7, MDA-MB 468, 293, HCT116, and A549 - SCBT Publication Review
Date published: 2015-03-22
Rated 4 out of 5 by from WB publishable data with human AU565WB publishable data with human AU565, BT474, BT549, HCC38, HCC1500, HCC1954, MB231, MB436, MB453, MB468, MCF7, SKBR3, T47D, and ZR75-1 - SCBT Publication Review
Date published: 2014-01-28
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DcR2 Antibody (B-P30) is rated 4.3 out of 5 by 3.
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