DC-SIGN Antibody (DCN47.5): sc-52660
- DC-SIGN Antibody (DCN47.5) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against DC-SIGN of human origin
- recommended for detection of DC-SIGN of human origin by FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DC-SIGN Antibody (DCN47.5). This work is in progress.
DC-SIGN Antibody (DCN47.5) is a mouse monoclonal IgG1 antibody that detects DC-SIGN in human samples through flow cytometry (FCM). DC-SIGN, also known as CD209, is a type II membrane protein predominantly expressed on dendritic cells (DCs), which play a crucial role in the immune response by presenting antigens to T cells. The unique structure of DC-SIGN, featuring a C-type lectin domain, allows DC-SIGN to bind specifically to ICAM-3, facilitating the initial interaction between DCs and resting T cells at the immunological synapse. This interaction is vital for T cell activation, particularly in HIV-1 infection, where DC-SIGN captures the virus at mucosal surfaces and transports HIV-1 to lymphoid tissues. By promoting efficient trans-infection of T cells, DC-SIGN serves as a key player in the immune system′s response to pathogens, making DC-SIGN an important target for research and therapeutic interventions. Anti-DC-SIGN antibody (DCN47.5) is an essential tool for studying dendritic cell interactions and their implications in immune responses and viral infections.
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DC-SIGN Antibody (DCN47.5) References:
- Human immunodeficiency virus envelope (gp120) binding to DC-SIGN and primary dendritic cells is carbohydrate dependent but does not involve 2G12 or cyanovirin binding sites: implications for structural analyses of gp120-DC-SIGN binding. | Hong, PW., et al. 2002. J Virol. 76: 12855-65. PMID: 12438611
- Pathogens target DC-SIGN to influence their fate DC-SIGN functions as a pathogen receptor with broad specificity. | Geijtenbeek, TB. and van Kooyk, Y. 2003. APMIS. 111: 698-714. PMID: 12974773
- Role of N-acetylglucosamine within core lipopolysaccharide of several species of gram-negative bacteria in targeting the DC-SIGN (CD209). | Zhang, P., et al. 2006. J Immunol. 177: 4002-11. PMID: 16951363
- Dermal-type macrophages expressing CD209/DC-SIGN show inherent resistance to dengue virus growth. | Kwan, WH., et al. 2008. PLoS Negl Trop Dis. 2: e311. PMID: 18827881
- Pathogen recognition by DC-SIGN shapes adaptive immunity. | Geijtenbeek, TB., et al. 2009. Future Microbiol. 4: 879-90. PMID: 19722841
- C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity. | Svajger, U., et al. 2010. Cell Signal. 22: 1397-405. PMID: 20363321
- DC-SIGN-LEF1/TCF1-miR-185 feedback loop promotes colorectal cancer invasion and metastasis. | Yuan, M., et al. 2020. Cell Death Differ. 27: 379-395. PMID: 31217502
- Poly-l-lysine Glycoconjugates Inhibit DC-SIGN-mediated Attachment of Pandemic Viruses. | Cramer, J., et al. 2021. ChemMedChem. 16: 2345-2353. PMID: 34061468
- DC-SIGN targets amphotericin B-loaded liposomes to diverse pathogenic fungi. | Ambati, S., et al. 2021. Fungal Biol Biotechnol. 8: 22. PMID: 34952645
- Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes. | Nieto-Fabregat, F., et al. 2024. JACS Au. 4: 697-712. PMID: 38425910
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DC-SIGN Antibody (DCN47.5) | sc-52660 | 100 µg/ml | $316.00 |