DC-SIGN Antibody (8C1): sc-53580
- DC-SIGN Antibody (8C1) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against DC-SIGN of pig tailed macaque origin
- DC-SIGN Antibody (8C1) is recommended for detection of DC-SIGN of human origin and CD209e of mouse and rat origin by WB, IP and FCM; also reactive with additional species, including and pig tailed macaque and porcine
- Anti-DC-SIGN Antibody (8C1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DC-SIGN Antibody (8C1). This work is in progress.
DC-SIGN Antibody (8C1) is a mouse monoclonal IgG1 kappa light chain antibody that detects DC-SIGN of human origin and CD209e of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). anti-DC-SIGN antibody (8C1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dendritic cells (DCs), which express DC-SIGN, play a crucial role in the immune system as antigen-presenting cells located in peripheral mucosal tissues that migrate to lymphoid tissues. DC-SIGN (8C1) monoclonal antibody recognizes a type II membrane protein that facilitates binding to intercellular adhesion molecule 3 (ICAM-3), mediating the initial interaction between dendritic cells and resting T cells through the immunological synapse. This interaction is vital for the immune response, especially in HIV-1 infection, as DC-SIGN enables dendritic cells to capture HIV-1 at mucosal surfaces and transport it to lymphoid compartments, promoting efficient trans-infection of T cells. Understanding DC-SIGN′s structural characteristics helps researchers better appreciate its role in immune surveillance and viral infection pathogenesis, making anti-DC-SIGN antibody (8C1) an essential tool for studying these processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DC-SIGN Antibody (8C1) References:
- Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation. | Koppel, EA., et al. 2005. Cell Microbiol. 7: 157-65. PMID: 15659060
- The clinical significance of DC-SIGN and DC-SIGNR, which are novel markers expressed in human colon cancer. | Jiang, Y., et al. 2014. PLoS One. 9: e114748. PMID: 25504222
- Colorectal mucus binds DC-SIGN and inhibits HIV-1 trans-infection of CD4+ T-lymphocytes. | Stax, MJ., et al. 2015. PLoS One. 10: e0122020. PMID: 25793526
- Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGN. | Gillespie, L., et al. 2016. Sci Rep. 6: 19428. PMID: 26763587
- Differential Use of the C-Type Lectins L-SIGN and DC-SIGN for Phlebovirus Endocytosis. | Léger, P., et al. 2016. Traffic. 17: 639-56. PMID: 26990254
- Oligomerization domains in the glycan-binding receptors DC-SIGN and DC-SIGNR: Sequence variation and stability differences. | Dos Santos, Á., et al. 2017. Protein Sci. 26: 306-316. PMID: 27859859
- The mTOR-RUNX1 pathway regulates DC-SIGN expression in renal tubular epithelial cells. | Zhou, S., et al. 2019. Biochem Biophys Res Commun. 519: 620-625. PMID: 31540687
- Expression of DC-SIGN-like C-Type Lectin Receptors in Salmo salar. | Ojeda, N., et al. 2020. Dev Comp Immunol. 113: 103806. PMID: 32739503
- Combating DC-SIGN-mediated SARS-CoV-2 dissemination by glycan-mimicking polymers. | Cramer, J., et al. 2024. Arch Pharm (Weinheim). 357: e2300396. PMID: 38086006
- Vaccination with DC-SIGN-Targeting αGC Liposomes Leads to Tumor Control, Irrespective of Suboptimally Activated T-Cells. | de Haas, AM., et al. 2024. Pharmaceutics. 16: PMID: 38794243
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DC-SIGN Antibody (8C1) | sc-53580 | 200 µg/ml | $322.00 | |||
DC-SIGN Antibody (8C1) AC | sc-53580 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DC-SIGN Antibody (8C1) HRP | sc-53580 HRP | 200 µg/ml | $322.00 | |||
DC-SIGN Antibody (8C1) FITC | sc-53580 FITC | 200 µg/ml | $336.00 | |||
DC-SIGN Antibody (8C1) PE | sc-53580 PE | 200 µg/ml | $349.00 | |||
DC-SIGN Antibody (8C1) Alexa Fluor® 488 | sc-53580 AF488 | 200 µg/ml | $364.00 | |||
DC-SIGN Antibody (8C1) Alexa Fluor® 546 | sc-53580 AF546 | 200 µg/ml | $364.00 | |||
DC-SIGN Antibody (8C1) Alexa Fluor® 594 | sc-53580 AF594 | 200 µg/ml | $364.00 | |||
DC-SIGN Antibody (8C1) Alexa Fluor® 647 | sc-53580 AF647 | 200 µg/ml | $364.00 | |||
DC-SIGN Antibody (8C1) Alexa Fluor® 680 | sc-53580 AF680 | 200 µg/ml | $364.00 | |||
DC-SIGN Antibody (8C1) Alexa Fluor® 790 | sc-53580 AF790 | 200 µg/ml | $364.00 |