DBP Antibody (2B12): sc-69771
- DBP Antibody (2B12) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µl
- raised against purified DBP of human origin
- recommended for detection of DBP of human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DBP Antibody (2B12). This work is in progress.
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DBP Antibody (2B12) is a mouse monoclonal IgG1 antibody that detects Vitamin D-binding protein (DBP) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. DBP, also known as group-specific component protein or GC, is a multi-functional serum protein primarily located in the extracellular space, where DBP plays a crucial role in the transportation of vitamin D and its metabolites to target organs within the vitamin D endocrine system. DBP′s ability to bind to plasma membranes of various cell types is essential for mediating diverse cellular functions, including immunomodulatory properties, which enhance the chemotactic activity of C5a by acting as a co-chemotactic factor. Additionally, DBP′s interaction with globular actin is significant for the clearance of actin from the bloodstream, highlighting DBP′s importance in maintaining cellular homeostasis. DBP binding to cell surfaces through chondroitin sulfate proteoglycans is vital for osteoclast differentiation and other biological processes, underscoring DBP′s structural and functional integrity in various physiological contexts.
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DBP Antibody (2B12) References:
- Vitamin D-Binding Protein in Health and Chronic Kidney Disease. | Denburg, MR. and Bhan, I. 2015. Semin Dial. 28: 636-44. PMID: 26332676
- Vitamin D-binding protein as a biomarker to confirm specific clinical diagnoses. | Lisowska-Myjak, B., et al. 2020. Expert Rev Mol Diagn. 20: 49-56. PMID: 31795772
- Vitamin D-Binding Protein in Pregnancy and Reproductive Health. | Fernando, M., et al. 2020. Nutrients. 12: PMID: 32443760
- Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19. | Faniyi, AA., et al. 2021. Eur Respir J. 57: PMID: 33888522
- Potential roles of vitamin D binding protein in attenuating liver injury in sepsis. | Xiao, K., et al. 2022. Mil Med Res. 9: 4. PMID: 35057868
- Serum vitamin D-binding protein (VDBP) concentration and rs7041 genotype may be associated with preterm labor. | Cho, MC., et al. 2022. J Matern Fetal Neonatal Med. 35: 9422-9429. PMID: 35188037
- The Role of Vitamin D and Vitamin D Binding Protein in Chronic Liver Diseases. | Pop, TL., et al. 2022. Int J Mol Sci. 23: PMID: 36142636
- Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots. | Albiñana, C., et al. 2023. Nat Commun. 14: 852. PMID: 36792583
- Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma. | Qin, LN., et al. 2024. Theranostics. 14: 436-450. PMID: 38164156
- Vitamin D-Binding Protein and the Role of its Gene Polymorphisms in the Mortality of Sepsis Patients. | Kahar, LA., et al. 2023. Acta Med Acad. 52: 212-220. PMID: 38407088
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DBP Antibody (2B12) | sc-69771 | 100 µl | $322.00 |