Daxx Antibody (DAXX-01): sc-51586
- Daxx Antibody (DAXX-01) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against amino acids 558-740 of Daxx of human origin
- recommended for detection of Daxx of human origin by WB, IP and IF
- See Daxx (H-7): sc-8043 for Daxx antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Daxx Antibody (DAXX-01). This work is in progress.
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Daxx Antibody (DAXX-01) is a mouse monoclonal IgG1 antibody that detects Daxx in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Daxx is a multifunctional protein that plays a crucial role in the regulation of apoptosis, particularly in the context of the FAS signaling pathway. Daxx (DAXX-01) antibody targets proteins primarily located in the nucleus and cytoplasm of cells, where Daxx acts as a scaffold for various signaling molecules, thereby influencing cellular responses to stress and death signals. The localization of Daxx is significant because Daxx allows for the integration of multiple signaling pathways, including those involved in apoptosis and transcriptional regulation. Notably, Daxx interacts with several key proteins, including the death domain of FAS, which is essential for the initiation of apoptosis. This interaction highlights Daxx′s role as a mediator in the FAS pathway, linking extracellular death signals to intracellular apoptotic machinery. Furthermore, Daxx′s ability to modulate the activity of Jun N-terminal kinase (JNK) underscores its importance in cellular stress responses and the maintenance of tissue homeostasis. Anti-Daxx antibody (DAXX-01) serves as an invaluable tool for researchers studying apoptosis and related signaling pathways, providing insights into the complex mechanisms that govern cell fate decisions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Daxx Antibody (DAXX-01) References:
- Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. | Yang, Y., et al. 2019. Nat Commun. 10: 3759. PMID: 31434890
- DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos. | Bogolyubova, I. and Bogolyubov, D. 2021. Int J Mol Sci. 22: PMID: 33525665
- Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size. | Hackeng, WM., et al. 2022. Gut. 71: 961-973. PMID: 33849943
- DAXX represents a new type of protein-folding enabler. | Huang, L., et al. 2021. Nature. 597: 132-137. PMID: 34408321
- Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen. | Mac Kain, A., et al. 2022. Nat Commun. 13: 2442. PMID: 35508460
- DAXX drives de novo lipogenesis and contributes to tumorigenesis. | Mahmud, I., et al. 2023. Nat Commun. 14: 1927. PMID: 37045819
- ATR protects centromere identity by promoting DAXX association with PML nuclear bodies. | Trier, I., et al. 2023. Cell Rep. 42: 112495. PMID: 37163376
- The histone chaperone function of Daxx is dispensable for embryonic development. | Sun, C., et al. 2023. Cell Death Dis. 14: 565. PMID: 37633949
- DAXX safeguards heterochromatin formation in embryonic stem cells. | Canat, A., et al. 2023. J Cell Sci. 136: PMID: 37655670
- Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling. | Li, Y., et al. 2024. J Neuroinflammation. 21: 143. PMID: 38822367
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Daxx Antibody (DAXX-01) | sc-51586 | 100 µg/ml | $322.00 |