D1DR/Dopamine Receptor D1 Antibody (A-1): sc-518273

D1DR Antibody (A-1) is a monolconal antibody that detects D1DR protein in human, mouse and rat samples, making anti-D1DR antibody (A-1) a versatile tool for western blotting (WB), immunofluorescence (IF), and immunoprecipitation (IP). D1DR, also known as the dopamine D1 receptor, plays a crucial role in the central nervous system by mediating dopamine effects, a key neurotransmitter involved in regulating mood, cognition, and motor control. Proper functioning of D1DR is essential for maintaining neurological health, as dysregulation of dopamine signaling has been implicated in several neuropsychiatric disorders, including schizophrenia and Parkinson′s disease. Located primarily in the brain, particularly in areas such as the striatum and prefrontal cortex, D1DR′s strategic positioning allows for influence on neuronal signaling pathways and synaptic plasticity, which are vital for learning and memory processes. Furthermore, D1DR undergoes various post-translational modifications, including phosphorylation, which can modulate activity and interactions with other proteins, thereby affecting downstream signaling cascades. Using D1DR monoclonal antibody (A-1) in experiments can provide valuable insights into dopamine signaling in health and disease, enhancing our understanding of complex biological functions.

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D1DR/Dopamine Receptor D1 Antibody (A-1) References:

1. Genetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor.  |  Błasiak, E., et al. 2017. Pharmacol Rep. 69: 235-241. PMID: 28119185
2. Long-term subregion-specific encoding of enhanced ethanol intake by D1DR medium spiny neurons of the nucleus accumbens.  |  Renteria, R., et al. 2018. Addict Biol. 23: 689-698. PMID: 28656742
3. Projection targets of medial frontal D1DR-expressing neurons.  |  Han, SW., et al. 2017. Neurosci Lett. 655: 166-171. PMID: 28689051
4. Dopamine D1 receptor activation contributes to light-adapted changes in retinal inhibition to rod bipolar cells.  |  Flood, MD., et al. 2018. J Neurophysiol. 120: 867-879. PMID: 29847232
5. Cerebellar D1DR-expressing neurons modulate the frontal cortex during timing tasks.  |  Heskje, J., et al. 2020. Neurobiol Learn Mem. 170: 107067. PMID: 31404656
6. Nonlinear Effects of Dopamine D1 Receptor Activation on Visuomotor Coordination Task Performance.  |  Chen, PS., et al. 2020. Cereb Cortex. 30: 5346-5355. PMID: 32483622
7. Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure.  |  Yamaguchi, T., et al. 2020. Nat Commun. 11: 4364. PMID: 32868781
8. Dopamine D1 receptor alleviates doxorubicin-induced cardiac injury by inhibiting NLRP3 inflammasome.  |  Liu, J., et al. 2021. Biochem Biophys Res Commun. 561: 7-13. PMID: 33992835
9. The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus.  |  Puri, NM., et al. 2022. Elife. 11: PMID: 35467530
10. The Dopamine D1 Receptor Attenuates Titanium Particle-Induced Inhibition of Osteogenesis by Activating the Wnt Signaling Pathway.  |  Feng, C., et al. 2023. Mediators Inflamm. 2023: 6331650. PMID: 36700172
11. Dopamine D1-receptor-expressing pathway from the nucleus accumbens to ventral pallidum-mediated sevoflurane anesthesia in mice.  |  Zhang, J., et al. 2023. CNS Neurosci Ther. 29: 3364-3377. PMID: 37208941
12. Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits.  |  Sun, M., et al. 2024. Neuropsychopharmacology. 49: 1341-1351. PMID: 38658737

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-D1DR/Dopamine Receptor D1 Antibody (A-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-D1DR/Dopamine Receptor D1 Antibody (A-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

D1DR/Dopamine Receptor D1 Antibody (A-1) Specifications

Alternate Product Name: D1DR

Product Clone Name: A-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 320-446

Epitope Target: D1DR

Epitope Species: rat

Product Reactivity/Detection: D1DR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for D1DR/Dopamine Receptor D1 Antibody (A-1): N/A