D-Dimer Antibody (DD1): sc-51859

D-Dimer Antibody (DD1) is a mouse monoclonal IgG2a antibody that detects D-Dimer and high molecular weight fibrin degradation products of human origin by western blotting (WB) and immunoprecipitation (IP). D-Dimer plays a crucial role in the blood coagulation process, as it is the primary and smallest product of fibrin degradation, which occurs when fibrinogen, the main protein in the coagulation system, is activated by thrombin and subsequently polymerizes into fibrin. Following clot formation, plasmin digests the fibrin, releasing various degradation products into the bloodstream, with D-Dimer being a key indicator of fibrinolysis. The structure of D-Dimer consists of fragments derived from the α, β, and γ chains of fibrinogen, specifically comprising 111-197 amino acids in the α chain, 134-461 amino acids in the β chain, and 88-406 amino acids in the γ chain. These chains are interconnected by disulfide bonds, and the dimeric structure is stabilized by isopeptide bonds between the C-terminal regions of the γ chains. Measuring D-Dimer levels in plasma and whole blood is invaluable in clinical settings, as elevated levels can indicate the presence of thromboembolic disorders, making anti-D-Dimer antibody (DD1) an essential tool for diagnostic evaluation in venous thromboembolism.

The preferred D-Dimer antibody is D-Dimer Antibody (DD3): sc-51862.