D-Aspartic acid CAS: 1783-96-6
MF: C4H7NO4
MW: 133.1
An endogenous agonist of the NMDA receptor.

D-Aspartic acid (CAS 1783-96-6)

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Application: D-Aspartic acid is an endogenous agonist of the NMDA receptor
CAS Number: 1783-96-6
Purity: ≥99%
Molecular Weight: 133.1
Molecular Formula: C4H7NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

D-Aspartic acid is an endogenous NMDA receptor agonist with similar activity to the L-isomer. It is also a non-metabolizable substrate for EAA uptake systems. It modulates melatonin synthesis in the pineal gland.


References

Olverman et al (1988) Structure/activity relations of NMDA receptor ligands as studied by their inhibition of 3H-D-AP5 binding in rat brain membranes. Neuroscience 26 17. Hashimoto et al (1997) Free D-aspartate and D-serine in the mammalian brain and periphery. Progr.Neurobiol. 53 325. Ishio et al (1998) D-Aspartate modulates melatonin synthesis in rat pinealocytes. Neurosci.Lett. 249 143.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water, 1N NH4OH (100 mg/ml), and dilute HCl. Insoluble in ether, and alcohol.
Storage :
Store at room temperature
Melting Point :
>300° C (lit.)
Boiling Point :
264.12° C at 760 mmHg (Predicted)
Density :
1.66 g/cm3 at 20° C
Refractive Index :
n20D 1.53 (Predicted)
Optical Activity :
α20/D -24°, c = 2.3 in 6 M HCl; α20/D -25°, c = 1 in 1N HCl; α20/D -26.45°±0.55°, c = 10 in 2N HCl
IC50 :
Glutamate NMDA receptor: IC50 = 10 µM (rat); mGluR-1a: EC5050 >1 mM (human); mGluR-2: EC5050 >1 mM (human); mGluR-6: EC5050 >1 mM (human)
pK Values :
pKa: 2.28 (Predicted), pKb: 9.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
CI9097500
PubChem CID :
83887
Merck Index :
14: 840
MDL Number :
MFCD00063081
EC Number :
217-234-6
Beilstein Registry :
1723529
SMILES :
C(C(C(=O)O)N)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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