Cytokeratin 8 Antibody (LP3K): sc-53266

Cytokeratin 8 Antibody (LP3K) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 8 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. Cytokeratin 8 is a vital component of the cytoskeletal structure in epithelial cells, playing a crucial role in maintaining cellular integrity and providing mechanical support. Anti-Cytokeratin 8 antibody (LP3K) targets proteins predominantly located in the cytoplasm of simple epithelial cells, where Cytokeratin 8 forms intermediate filaments that contribute to the overall architecture of tissues. Cytokeratin 8 expression is particularly significant in epithelial differentiation and tissue specialization, as expression patterns often change in various malignancies. For instance, in squamous cell carcinomas derived from stratified epithelia, abnormal Cytokeratin 8 expression can be observed, which may indicate a shift in cellular phenotype associated with malignancy. Furthermore, Cytokeratin 8 expression has been identified as an independent prognostic marker in oral squamous cell carcinomas, correlating with poor patient outcomes. The ability of Cytokeratin 8 to present extracellular epitopes on tumor cells also highlights potential therapeutic targeting opportunities, making Cytokeratin 8 monoclonal antibody (LP3K) an essential tool for researchers investigating epithelial cell biology and cancer pathology.

The preferred Cytokeratin 8 antibody is Cytokeratin 8 Antibody (C51): sc-8020.