Cytokeratin 8 Antibody (H-11): sc-374027
- Cytokeratin 8 Antibody (H-11) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 11-50 mapping near the N-terminus of Cytokeratin 8 of human origin
- recommended for detection of Cytokeratin 8 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See Cytokeratin 8 (C51): sc-8020 for Cytokeratin 8 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Cytokeratin 8 Antibody (H-11) for WB and IHC(P) applications. These reagents are now offered in bundles with Cytokeratin 8 Antibody (H-11) (see ordering information below).
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SEE ALSO...
Cytokeratin 8 Antibody (H-11) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 8 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Cytokeratin 8 is a vital component of the cytoskeleton in epithelial cells, playing a crucial role in maintaining cellular integrity and providing mechanical support. Anti-Cytokeratin 8 antibody (H-11) targets proteins predominantly located in the cytoplasm of simple epithelial cells, where Cytokeratin 8 forms intermediate filaments that contribute to the structural framework of tissues. Cytokeratin 8 expression is particularly important in epithelial differentiation and tissue specialization, as expression patterns often change in various malignancies. For instance, in squamous cell carcinomas derived from stratified epithelia, abnormal Cytokeratin 8 expression can indicate a shift in cellular phenotype associated with malignancy. Additionally, Cytokeratin 8 expression has been identified as an independent prognostic marker in oral squamous cell carcinomas, correlating with poor patient outcomes. Cytokeratin 8′s ability to present extracellular epitopes on tumor cells highlights potential therapeutic applications, making Cytokeratin 8 monoclonal antibody (H-11) an invaluable tool for studying epithelial biology and cancer pathology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 8 Antibody (H-11) | sc-374027 | 200 µg/ml | $316.00 | |||
Cytokeratin 8 Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-540415 | 200 µg Ab; 10 µg BP | $354.00 | |||
Cytokeratin 8 Antibody (H-11): m-IgG1 BP-HRP Bundle | sc-542105 | 200 µg Ab; 20 µg BP | $354.00 |