Cytokeratin 8 Antibody (E-12): sc-374274
- Cytokeratin 8 Antibody (E-12) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 11-50 mapping near the N-terminus of Cytokeratin 8 of human origin
- recommended for detection of Cytokeratin 8 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See Cytokeratin 8 (C51): sc-8020 for Cytokeratin 8 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Cytokeratin 8 Antibody (E-12) for WB and IHC(P) applications. These reagents are now offered in bundles with Cytokeratin 8 Antibody (E-12) (see ordering information below).
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SEE ALSO...
Cytokeratin 8 Antibody (E-12) is a mouse monoclonal IgG2a antibody that detects Cytokeratin 8 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Cytokeratin 8 is a vital component of the cytoskeletal structure in epithelial cells, playing a crucial role in maintaining cellular integrity and providing mechanical support. Expression of Cytokeratin 8 is particularly significant in simple epithelia, where Cytokeratin 8 pairs with Cytokeratin 18, and serves as a marker for tissue differentiation. Notably, abnormal expression of Cytokeratin 8 in squamous cell carcinomas derived from stratified epithelia raises questions about Cytokeratin 8′s potential role in tumorigenesis, as Cytokeratin 8 has been associated with poor prognostic outcomes in oral squamous cell carcinomas and other malignancies. Detection of Cytokeratin 8 in non-small-cell lung cancers further underscores Cytokeratin 8′s relevance in cancer research, as Cytokeratin 8 may serve as a target for therapeutic interventions due to extracellular epitopes on tumor cells. Anti-Cytokeratin 8 antibody (E-12) is therefore an essential tool for researchers investigating epithelial cell biology and the implications of cytokeratin expression in cancer progression.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 8 Antibody (E-12) | sc-374274 | 200 µg/ml | $322.00 | |||
Cytokeratin 8 Antibody (E-12): m-IgG Fc BP-HRP Bundle | sc-540429 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cytokeratin 8 Antibody (E-12): m-IgG2a BP-HRP Bundle | sc-546905 | 200 µg Ab; 10 µg BP | $361.00 |