Cytokeratin 8 Antibody (1E8): sc-58736
- Cytokeratin 8 Antibody (1E8) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- raised against C-terminal amino acids 472-483 of Cytokeratin 8 of human origin
- recommended for detection of of human origin by WB, IP, IF and IHC(P); also reactive with additional species, including bovine
- See Cytokeratin 8 (C51): sc-8020 for Cytokeratin 8 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Cytokeratin 8 Antibody (1E8) for WB and IHC(P) applications. These reagents are now offered in bundles with Cytokeratin 8 Antibody (1E8) (see ordering information below).
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SEE ALSO...
Cytokeratin 8 Antibody (1E8) is a mouse monoclonal IgG2a antibody that detects Cytokeratin 8 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Cytokeratin 8 is a vital component of the cytoskeletal structure in epithelial cells, playing a crucial role in maintaining cellular integrity and providing mechanical support. Cytokeratin 8 is predominantly located in the cytoplasm of simple epithelial cells, where Cytokeratin 8 forms intermediate filaments that contribute to the overall architecture of the tissue. Cytokeratin 8 presence is particularly important in epithelial differentiation and tissue specialization, serving as a marker for various epithelial-derived tumors. Notably, abnormal Cytokeratin 8 expression has been associated with squamous cell carcinomas, indicating a potential role in tumor progression and malignancy. Furthermore, Cytokeratin 8 expression in oral squamous cell carcinomas has been identified as an independent prognostic marker, suggesting that Cytokeratin 8 levels can provide valuable insights into patient outcomes. Unique extracellular Cytokeratin 8 epitopes on tumor cells also present promising targets for therapeutic interventions, making anti-Cytokeratin 8 antibody (1E8) an essential tool for researchers studying epithelial biology and cancer pathology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 8 Antibody (1E8) | sc-58736 | 200 µg/ml | $322.00 | |||
Cytokeratin 8 Antibody (1E8): m-IgG Fc BP-HRP Bundle | sc-539095 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cytokeratin 8 Antibody (1E8): m-IgG2a BP-HRP Bundle | sc-546670 | 200 µg Ab; 10 µg BP | $361.00 |