Cytokeratin 8 Antibody (1E8-C6-B4): sc-73480
- Cytokeratin 8 Antibody (1E8-C6-B4) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against C-terminal amino acids 472-483 of Cytokeratin 8 of human origin
- recommended for detection of Cytokeratin 8 of human origin by WB, IP and IF; also reactive with additional species, including bovine
- See Cytokeratin 8 (C51): sc-8020 for Cytokeratin 8 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Cytokeratin 8 Antibody (1E8-C6-B4) for WB applications. This reagent is now offered in a bundle with Cytokeratin 8 Antibody (1E8-C6-B4) (see ordering information below).
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SEE ALSO...
Cytokeratin 8 Antibody (1E8-C6-B4) is a mouse monoclonal IgG2a antibody that detects Cytokeratin 8 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Cytokeratin 8 is a vital component of the cytoskeletal structure in epithelial cells, playing a crucial role in maintaining cellular integrity and providing mechanical support. Anti-Cytokeratin 8 antibody (1E8-C6-B4) recognizes proteins predominantly located in the cytoplasm of simple epithelial cells, where Cytokeratin 8 forms intermediate filaments that contribute to the overall architecture of the tissue. Cytokeratin 8 expression is particularly significant in epithelial differentiation and tissue specialization, as expression patterns often change in various malignancies. In squamous cell carcinomas derived from stratified epithelia, abnormal Cytokeratin 8 expression can indicate a shift in cellular phenotype associated with tumor progression. Cytokeratin 8 monoclonal antibody (1E8-C6-B4) has helped identify this protein as an independent prognostic marker in oral squamous cell carcinomas, correlating with poor patient outcomes. Cytokeratin 8 extracellular epitopes on tumor cells present potential therapeutic targets, making this protein a critical focus in cancer research and treatment strategies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 8 Antibody (1E8-C6-B4) | sc-73480 | 200 µg/ml | $322.00 | |||
Cytokeratin 8 Antibody (1E8-C6-B4): m-IgG Fc BP-HRP Bundle | sc-539485 | 200 µg Ab; 10 µg BP | $361.00 |