Cytokeratin 8 Antibody (1E8-C6-B4): sc-73480

Cytokeratin 8 Antibody (1E8-C6-B4) is a mouse monoclonal IgG2a antibody that detects Cytokeratin 8 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Cytokeratin 8 is a vital component of the cytoskeletal structure in epithelial cells, playing a crucial role in maintaining cellular integrity and providing mechanical support. Anti-Cytokeratin 8 antibody (1E8-C6-B4) recognizes proteins predominantly located in the cytoplasm of simple epithelial cells, where Cytokeratin 8 forms intermediate filaments that contribute to the overall architecture of the tissue. Cytokeratin 8 expression is particularly significant in epithelial differentiation and tissue specialization, as expression patterns often change in various malignancies. In squamous cell carcinomas derived from stratified epithelia, abnormal Cytokeratin 8 expression can indicate a shift in cellular phenotype associated with tumor progression. Cytokeratin 8 monoclonal antibody (1E8-C6-B4) has helped identify this protein as an independent prognostic marker in oral squamous cell carcinomas, correlating with poor patient outcomes. Cytokeratin 8 extracellular epitopes on tumor cells present potential therapeutic targets, making this protein a critical focus in cancer research and treatment strategies.

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Cytokeratin 8 Antibody (1E8-C6-B4) References:

1. Cytokeratin 8 functions as a major plasminogen receptor in select epithelial and carcinoma cells.  |  Gonias, SL., et al. 2001. Front Biosci. 6: D1403-11. PMID: 11689350
2. Coordinate expression of cytokeratin 8 and cytokeratin 17 immunohistochemical staining in cervical intraepithelial neoplasia and cervical squamous cell carcinoma: an immunohistochemical analysis and review of the literature.  |  Ikeda, K., et al. 2008. Gynecol Oncol. 108: 598-602. PMID: 18191996
3. Cytokeratin 8 silencing in human nasopharyngeal carcinoma cells leads to cisplatin sensitization.  |  Wang, Y., et al. 2008. Cancer Lett. 265: 188-96. PMID: 18353540
4. Cytokeratin 8 is expressed in human corneoconjunctival epithelium, particularly in limbal epithelial cells.  |  Merjava, S., et al. 2011. Invest Ophthalmol Vis Sci. 52: 787-94. PMID: 20926822
5. Cytokeratin 8 and 18 tissue expression in gallbladder mucosa of patients with cholelithiasis.  |  Kasprzak, A., et al. 2011. Pol J Pathol. 62: 241-9. PMID: 22246910
6. An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18 expression in breast papillomas and papillary carcinomas.  |  Wang, Y., et al. 2013. Diagn Pathol. 8: 8. PMID: 23327593
7. Cytokeratin 8 is increased in hepatitis C virus cells and its ectopic expression induces apoptosis of SMMC7721 cells.  |  Sun, MZ., et al. 2013. World J Gastroenterol. 19: 6178-87. PMID: 24115814
8. Cytokeratin-8 in Anaplastic Thyroid Carcinoma: More Than a Simple Structural Cytoskeletal Protein.  |  Guo, D., et al. 2018. Int J Mol Sci. 19: PMID: 29443941
9. Cytokeratin 8/18 protects breast cancer cell lines from TRAIL-induced apoptosis.  |  Bozza, WP., et al. 2018. Oncotarget. 9: 23264-23273. PMID: 29796187
10. Cytokeratin 8 depicts nodal metastasis in head and neck squamous cell carcinoma.  |  Thamilselvan, S., et al. 2024. J Oral Maxillofac Pathol. 28: 247-252. PMID: 39157840

The preferred Cytokeratin 8 antibody is Cytokeratin 8 Antibody (C51): sc-8020.