Cytokeratin 5/14 Antibody (16.4): sc-58733

Cytokeratin 5/14 Antibody (16.4) is a mouse monoclonal IgG2a antibody that detects Cytokeratin 5/14 in human and feline samples through flow cytometry (FCM). Cytokeratin 5 and Cytokeratin 14 are crucial components of the cytoskeletal structure in epithelial cells, primarily found in the basal layer of stratified squamous epithelia, such as the skin and the lining of the esophagus. Anti-Cytokeratin 5/14 antibody (16.4) helps maintain structural integrity and mechanical resilience of these tissues, particularly in response to physical stress and injury. Cytokeratin 5/14 monoclonal antibody (16.4) plays a key role in epithelial differentiation and development, as these proteins are often upregulated during inflammation and wound healing. These cytokeratins serve as important biomarkers in diagnosing epithelial tumors, as their expression patterns help distinguish between different types of malignancies. Cytokeratin 5/14 (16.4) antibody serves as an invaluable tool for researchers and clinicians studying epithelial cell biology and pathology.

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Cytokeratin 5/14 Antibody (16.4) References:

1. Dose-dependent linkage, assembly inhibition and disassembly of vimentin and cytokeratin 5/14 filaments through plectin's intermediate filament-binding domain.  |  Steinböck, FA., et al. 2000. J Cell Sci. 113 (Pt 3): 483-91. PMID: 10639335
2. Cytokeratin 5/14-positive breast cancer: true basal phenotype confined to BRCA1 tumors.  |  Laakso, M., et al. 2005. Mod Pathol. 18: 1321-8. PMID: 15990899
3. The diagnostic value of cytokeratin 5/6, 14, 17, and 18 expression in human non-small cell lung cancer.  |  Chen, Y., et al. 2011. Oncology. 80: 333-40. PMID: 21791943
4. An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18 expression in breast papillomas and papillary carcinomas.  |  Wang, Y., et al. 2013. Diagn Pathol. 8: 8. PMID: 23327593
5. Cytokeratin 14 and cytokeratin 18 expressions in reduced enamel epithelium and dentigerous cyst: Possible role in oncofetal transformation and histogenesis- of follicular type of adenomatoid odontogenic tumor.  |  Shruthi, DK., et al. 2014. J Oral Maxillofac Pathol. 18: 365-71. PMID: 25948990
6. Cytokeratin 5/6 expression, prognosis, and association with estrogen receptor α in high-grade serous ovarian carcinoma.  |  Taube, ET., et al. 2017. Hum Pathol. 67: 30-36. PMID: 28414091
7. Lung Diffuse Neuroendocrine Hyperplasia: Relevance of Cytokeratin 5/6.  |  Handra-Luca, A. 2020. Appl Immunohistochem Mol Morphol. 28: e72-e73. PMID: 31789822
8. Cytokeratin 5 alters β-catenin dynamics in breast cancer cells.  |  McGinn, O., et al. 2020. Oncogene. 39: 2478-2492. PMID: 31988452
9. Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis.  |  Zhang, X., et al. 2021. Cell Death Dis. 12: 867. PMID: 34556631
10. Altered cytokeratin 5 expression in breast lobular myoepithelial cells.  |  Li, A., et al. 2024. J Clin Pathol. 77: 536-543. PMID: 37116947

The preferred Cytokeratin 14 antibody is Cytokeratin 14 Antibody (LL001): sc-53253.