CYP7B1 Antibody (WW-H9): sc-134309
- CYP7B1 Antibody (WW-H9) is a mouse monoclonal IgG2a κ CYP7B1 antibody provided at 100 µg/ml
- raised against recombinant CYP7B1 protein of human origin
- recommended for detection of CYP7B1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CYP7B1 Antibody (WW-H9). This work is in progress.
CYP7B1 Antibody (WW-H9) is a mouse monoclonal IgG2a kappa light chain antibody that detects CYP7B1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). CYP7B1 (WW-H9) antibody is available as a non-conjugated anti-CYP7B1 monoclonal isotype antibody. CYP7B1 protein, also known as oxysterol 7-alpha-hydroxylase, plays a crucial role in the alternative bile acid synthesis pathway by metabolizing 25- and 27-hydroxycholesterol, which are important intermediates in cholesterol metabolism. This enzymatic activity is vital for maintaining cholesterol homeostasis and regulating bile acid levels, which are essential for proper digestion and absorption of dietary fats. The gene encoding human CYP7B1 is located on chromosome 8q21.3, and mutations in this gene can lead to significant metabolic disorders, including elevated urinary bile acid excretion, severe cholestasis, cirrhosis, and liver synthetic failure. Understanding the function of CYP7B1 and its metabolic pathways is important for developing therapeutic strategies for conditions related to bile acid synthesis and cholesterol metabolism.
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CYP7B1 Antibody (WW-H9) References:
- Disruption of the oxysterol 7alpha-hydroxylase gene in mice. | Li-Hawkins, J., et al. 2000. J Biol Chem. 275: 16536-42. PMID: 10748048
- Metabolism of vitamin D(3) by human CYP27A1. | Sawada, N., et al. 2000. Biochem Biophys Res Commun. 273: 977-84. PMID: 10891358
- Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. | Repa, JJ., et al. 2000. Science. 289: 1524-9. PMID: 10968783
- Molecular cloning and expression of rabbit sterol 12alpha-hydroxylase. | Eggertsen, G., et al. 1996. J Biol Chem. 271: 32269-75. PMID: 8943286
- P450BM-3; a tale of two domains--or is it three? | Peterson, JA., et al. 1997. Steroids. 62: 117-23. PMID: 9029725
- Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease. | Setchell, KD., et al. 1998. J Clin Invest. 102: 1690-703. PMID: 9802883
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CYP7B1 Antibody (WW-H9) | sc-134309 | 100 µg/ml | $333.00 |