CYP4A1 Antibody (h1): sc-73580

CYP4A1 Antibody (h1) is a mouse monoclonal IgG1 antibody that detects CYP4A1 in mouse and rat samples through applications such as western blotting (WB) and immunoprecipitation (IP). CYP4A1 is a member of the cytochrome P450 family, which plays a crucial role in the metabolism of various endogenous compounds, including fatty acids and steroids, as well as the detoxification of exogenous substances like drugs and toxins. CYP4A1 is primarily located in the liver, where CYP4A1 is involved in the omega-hydroxylation of fatty acids and the synthesis of bioactive lipids, making CYP4A1 essential for maintaining lipid homeostasis and regulating inflammatory responses. CYP4A1 expression can be significantly induced by certain hypolipidemic agents, highlighting CYP4A1′s importance in pharmacological responses and metabolic regulation. Additionally, CYP4A1 interacts with various other proteins, including those involved in lipid metabolism and signaling pathways, which further underscores CYP4A1′s role in cellular processes and potential implications in disease states. With specificity for mouse and rat tissues, anti-CYP4A1 antibody (h1) is an invaluable tool for researchers studying metabolic pathways and the effects of drug metabolism in these species.

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CYP4A1 Antibody (h1) References:

1. Transfection of CYP4A1 cDNA increases vascular reactivity in renal interlobar arteries.  |  Kaide, J., et al. 2003. Am J Physiol Renal Physiol. 284: F51-6. PMID: 12388396
2. Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels.  |  Jiang, M., et al. 2004. Circ Res. 94: 167-74. PMID: 14670847
3. Transfection of CYP4A1 cDNA decreases diameter and increases responsiveness of gracilis muscle arterioles to constrictor stimuli.  |  Zhang, F., et al. 2004. Am J Physiol Heart Circ Physiol. 287: H1089-95. PMID: 15130884
4. Transfection and functional expression of CYP4A1 and CYP4A2 using bicistronic vectors in vascular cells and tissues.  |  Wang, JS., et al. 2004. J Pharmacol Exp Ther. 311: 913-20. PMID: 15269250
5. Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo.  |  Guo, AM., et al. 2008. J Pharmacol Exp Ther. 327: 10-9. PMID: 18591218
6. Induction of apoptosis and CYP4A1 expression in Sprague-Dawley rats exposed to low doses of perfluorooctane sulfonate.  |  Kim, HS., et al. 2011. J Toxicol Sci. 36: 201-10. PMID: 21467747
7. Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.  |  Tunctan, B., et al. 2013. Nitric Oxide. 33: 18-41. PMID: 23684565
8. [Effects of perfluorooctanoic acid on oxidative stress and PPARα and its related CYP4A1 gene expression in rat liver].  |  Wang, L., et al. 2017. Wei Sheng Yan Jiu. 46: 802-806. PMID: 29903312
9. Regulation of CYP4A1 and peroxisome proliferator-activated receptor alpha expression by interleukin-1beta, interleukin-6, and dexamethasone in cultured fetal rat hepatocytes.  |  Parmentier, JH., et al. 1997. Biochem Pharmacol. 54: 889-98. PMID: 9354589
10. Glu-320 and Asp-323 are determinants of the CYP4A1 hydroxylation regiospecificity and resistance to inactivation by 1-aminobenzotriazole.  |  Dierks, EA., et al. 1998. Biochemistry. 37: 1839-47. PMID: 9485309

The preferred CYP4A1 antibody is CYP4A1 Antibody (clo1): sc-53248.