CYP3A Antibody (D-2): sc-271033
- CYP3A Antibody (D-2) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 204-503 mapping at the C-terminus of CYP3A of human origin
- recommended for detection of all CYP3A family members of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG1 BP-HRP is the preferred secondary detection reagent for CYP3A Antibody (D-2) for WB applications. This reagent is now offered in a bundle with CYP3A Antibody (D-2) (see ordering information below).
CYP3A Antibody (D-2) is a mouse monoclonal IgG1 antibody that detects CYP3A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CYP3A is a crucial member of the cytochrome P450 family, primarily involved in the metabolism of a wide range of drugs, making CYP3A essential for pharmacokinetics and drug interactions. CYP3A is predominantly located in the liver, gastrointestinal tract, and kidneys, which are key organs for drug metabolism and excretion. CYP3A localization in these tissues directly influences the bioavailability and clearance of therapeutic agents, thereby impacting drug efficacy and safety. The CYP3A gene cluster, which includes CYP3A4, CYP3A5, CYP3A7, and CYP3A43, is responsible for metabolizing over 50% of all clinical drugs, highlighting CYP3A′s importance in personalized medicine and the need for careful monitoring of drug interactions. The CYP3A cluster is mapped to the gene locus 7q22.1, and understanding CYP3A expression and regulation can provide insights into individual variations in drug metabolism, ultimately guiding more effective treatment strategies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CYP3A Antibody (D-2) | sc-271033 | 200 µg/ml | $322.00 | |||
CYP3A Antibody (D-2): m-IgG1 BP-HRP Bundle | sc-542674 | 200 µg Ab; 20 µg BP | $361.00 |