CYP2B1/2B2 Antibody (11II D12A2): sc-73421

CYP2B1/2B2 Antibody (11II D12A2) is a mouse monoclonal IgG1 antibody that detects CYP2B1/2B2 in mouse and rat samples through western blotting (WB) and immunoprecipitation (IP) applications. CYP2B1 and CYP2B2 are critical members of the cytochrome P450 (CYP2) superfamily, which plays a vital role in the metabolism of various endogenous and exogenous compounds, including therapeutic agents and fatty acids. CYP2B1/2B2 (11II D12A2) antibody recognizes these enzymes primarily in the liver, where they facilitate the oxidation of substances, thereby influencing drug metabolism and detoxification processes. The liver serves as the central organ for drug metabolism, and CYP2B1 and CYP2B2 activity can significantly affect the pharmacokinetics of numerous medications. CYP2B1 converts ifosfamide into active cytotoxic metabolites, while CYP2B2 is involved in phenobarbital induction, highlighting their roles in both therapeutic efficacy and potential drug interactions. Anti-CYP2B1/2B2 antibody (11II D12A2) serves as an essential tool for researchers studying drug metabolism and the physiological effects of cytochrome P450 enzymes.

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CYP2B1/2B2 Antibody (11II D12A2) References:

1. Phenobarbital responsiveness conferred by the 5'-flanking region of the rat CYP2B2 gene in transgenic mice.  |  Ramsden, R., et al. 1999. Gene. 228: 169-79. PMID: 10072770
2. Spurious observation of splenic cyp2b1 expression.  |  Sharma, MR., et al. 2003. Drug Metab Dispos. 31: 1074-6. PMID: 12920159
3. Comparison of genomic and cDNA sequences of guinea pig CYP2B18 and rat CYP2B2: absence of a phenobarbital-responsive enhancer module in the upstream region of the CYP2B18 gene.  |  Yamamoto, M., et al. 2004. J Biochem Mol Toxicol. 18: 124-30. PMID: 15252867
4. Styrene monomer primarily induces CYP2B1 mRNA in rat liver.  |  Hirasawa, F., et al. 2005. Xenobiotica. 35: 1089-99. PMID: 16418063
5. Effect of sulfur dioxide inhalation on CYP2B1/2 and CYP2E1 in rat liver and lung.  |  Qin, G. and Meng, Z. 2006. Inhal Toxicol. 18: 581-8. PMID: 16717030
6. Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2.  |  Zhang, Q., et al. 2006. Arch Biochem Biophys. 451: 119-27. PMID: 16725103
7. Cell shape, cell-cell contact, cell-extracellular matrix contact and cell polarity are all required for the maximum induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes.  |  Oda, H., et al. 2008. Biochem Pharmacol. 75: 1209-17. PMID: 18164277
8. Structure-dependent induction of CYP2B1/2 by 3-methylsulfonyl metabolites of polychlorinated biphenyl congeners in rats.  |  Kato, Y., et al. 1997. Environ Toxicol Pharmacol. 3: 137-44. PMID: 21781771
9. Cancer prevention mediated by caffeic acid phenethyl ester involves cyp2b1/2 modulation in hepatocarcinogenesis.  |  Beltrán-Ramírez, O., et al. 2012. Toxicol Pathol. 40: 466-72. PMID: 22291063
10. Nuclear factor-1 motif and redundant regulatory elements comprise phenobarbital-responsive enhancer in CYP2B1/2.  |  Liu, S., et al. 1998. DNA Cell Biol. 17: 461-70. PMID: 9628589

The preferred CYP2B1/2B2 antibody is CYP2B1/2B2 Antibody (9.14): sc-73546.