CYP1A2 Antibody (16VII F10F12): sc-73476
- CYP1A2 Antibody (16VII F10F12) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against liver cytochrome P4501A2 of rat origin
- recommended for detection of CYP1A2 and, to a lesser extent, CYP1A1 of mouse, rat and human origin by WB and IP; not recommended for detection of rat CYP2A1, 2B1, 2B2, 2C6, 2C7, 2C11, 4A1, 4A2 and 4A3
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CYP1A2 Antibody (16VII F10F12). This work is in progress.
CYP1A2 Antibody (16VII F10F12) is a mouse monoclonal IgG1 antibody that detects CYP1A2 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). CYP1A2, also known as Cytochrome P450 1A2, is a crucial heme-thiolate monooxygenase enzyme that plays a significant role in the NADPH-dependent electron transport pathway of liver microsomes. This enzyme is essential for the oxidation of various substrates, including fatty acids, steroids, and xenobiotics, which are vital for drug metabolism and detoxification processes in the liver. Notably, CYP1A2 is involved in the metabolism of several important pharmaceuticals, such as imipramine, propranol, and clozapine, highlighting CYP1A2′s relevance in pharmacokinetics and personalized medicine. CYP1A2 is localized to the membrane of the endoplasmic reticulum, a critical site for metabolic reactions, ensuring efficient substrate processing. Furthermore, CYP1A2 is subject to induction by compounds like 3-methylcholanthrene, insulin, modafinil, and hyperforin, while CYP1A2 activity can be inhibited by various fluoroquinolone antibiotics, caffeine, fluvoxamine, and cimetidine. Importantly, CYP1A2′s involvement in estrogen metabolism has been linked to a reduced risk of breast cancer, underscoring CYP1A2′s potential impact on cancer biology and therapeutic strategies. With broad species reactivity and proven applications, anti-CYP1A2 antibody (16VII F10F12) is an invaluable tool for researchers studying drug metabolism and related health implications.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CYP1A2 Antibody (16VII F10F12) | sc-73476 | 200 µg/ml | $322.00 |