CYFIP2 Antibody (6-YD16): sc-134308

CYFIP2 Antibody (6-YD16) is a mouse monoclonal IgG2a kappa light chain antibody that detects CYFIP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CYFIP2 antibody (6-YD16) is available as a non-conjugated monoclonal isotype antibody. CYFIP2, also known as Cytoplasmic FMR1-interacting protein 2, is a 1,278 amino acid protein encoded by the human gene CYFIP2 and plays a crucial role in T-cell adhesion and p53-dependent induction of apoptosis. CYFIP2 is primarily located in the cytoplasm, where CYFIP2 interacts with several key proteins, including FMR1, FXR1, and FXR2, and is a vital component of the WAVE1 complex, which is essential for actin polymerization and cellular motility. CYFIP2 interaction with activated Rac1 leads to the dissociation of the WAVE1 complex, thereby releasing activated WASF1, which is critical for the regulation of cytoskeletal dynamics. Additionally, CYFIP2 promoter contains a p53-responsive element that facilitates p53 binding and transcriptional activation, highlighting CYFIP2′s importance in cellular stress responses. Induced expression of CYFIP2 is sufficient to trigger caspase activation and cellular apoptosis, mimicking the effects of p53 activation, making CYFIP2 a significant player in the pathways that govern cell survival and death.

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CYFIP2 Antibody (6-YD16) References:

1. A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.  |  Schenck, A., et al. 2001. Proc Natl Acad Sci U S A. 98: 8844-9. PMID: 11438699
2. CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.  |  Schenck, A., et al. 2003. Neuron. 38: 887-98. PMID: 12818175
3. CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion.  |  Mayne, M., et al. 2004. Eur J Immunol. 34: 1217-27. PMID: 15048733
4. Evolutionarily conserved human targets of adenosine to inosine RNA editing.  |  Levanon, EY., et al. 2005. Nucleic Acids Res. 33: 1162-8. PMID: 15731336
5. CYFIP2, a direct p53 target, is leptomycin-B sensitive.  |  Jackson, RS., et al. 2007. Cell Cycle. 6: 95-103. PMID: 17245118
6. Abelson interactor protein-1 positively regulates breast cancer cell proliferation, migration, and invasion.  |  Wang, C., et al. 2007. Mol Cancer Res. 5: 1031-9. PMID: 17951403
7. Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis.  |  Coussens, AK., et al. 2007. BMC Genomics. 8: 458. PMID: 18076769

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CYFIP2 Antibody (6-YD16) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CYFIP2 Antibody (6-YD16) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CYFIP2 Antibody (6-YD16) Specifications

Alternate Product Name: CYFIP2

Product Clone Name: 6-YD16

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 733-821

Epitope Target: CYFIP2

Epitope Species: human

Product Reactivity/Detection: CYFIP2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CYFIP2 Antibody (6-YD16): N/A