Cyclophilin G Antibody (8S5): sc-100699

Cyclophilin G Antibody (8S5) is a mouse monoclonal IgG2a kappa light chain antibody that detects Cyclophilin G protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Cyclophilin G antibody (8S5) is available as a non-conjugated format. Cyclophilin G, also known as CARS-Cyp (Clk-associating RS-cyclophilin), SRcyp (SR-cyclophilin), CASP10, PPIase G, or Rotamase G, is a crucial member of the Moca family of cyclophilins, which are highly conserved and abundant cytosolic peptidyl-prolyl cis-trans isomerases. These proteins play a vital role in accelerating the isomerization of XaaPro peptide bonds, thereby facilitating proper protein folding, essential for maintaining cellular function and homeostasis. Cyclophilin G is predominantly localized in the nucleus and, during interphase, is found in nuclear speckles, where Cyclophilin G is involved in pre-mRNA splicing regulation. Cyclophilin G features an N-terminal cyclophilin-type domain, an acidic serine-rich region, and five Cdc2-type phosphorylation sites, along with serine-arginine repeats at the C-terminus. Notably, Cyclophilin G undergoes phosphorylation during mitosis by the Cdc2-cyclin B complex, indicating activity regulation throughout the cell cycle. Additionally, Cyclophilin G interacts with Pinin and the C-terminus of the largest subunit of RNA polymerase II (Pol II), suggesting involvement in dynamic regulation of gene expression and splicing processes.

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Cyclophilin G Antibody (8S5) References:

1. The human nuclear SRcyp is a cell cycle-regulated cyclophilin.  |  Dubourg, B., et al. 2004. J Biol Chem. 279: 22322-30. PMID: 15016823
2. Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles.  |  Lin, CL., et al. 2004. Biochem Biophys Res Commun. 321: 638-47. PMID: 15358154
3. Loss of Pnn expression attenuates expression levels of SR family splicing factors and modulates alternative pre-mRNA splicing in vivo.  |  Chiu, Y. and Ouyang, P. 2006. Biochem Biophys Res Commun. 341: 663-71. PMID: 16430868
4. Association of the expression of an SR-cyclophilin with myeloid cell differentiation.  |  Giardina, SL., et al. 1996. Blood. 87: 2269-74. PMID: 8630387
5. RS cyclophilins: identification of an NK-TR1-related cyclophilin.  |  Nestel, FP., et al. 1996. Gene. 180: 151-5. PMID: 8973360
6. A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II.  |  Bourquin, JP., et al. 1997. Nucleic Acids Res. 25: 2055-61. PMID: 9153302

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cyclophilin G Antibody (8S5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Cyclophilin G Antibody (8S5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cyclophilin G Antibody (8S5) Specifications

Alternate Product Name: Cyclophilin G

Product Clone Name: 8S5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 13-107

Epitope Target: Cyclophilin G

Epitope Species: human

Product Reactivity/Detection: Cyclophilin G

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Cyclophilin G Antibody (8S5): N/A