cyclin D2 Antibody (A-1): sc-166288

Cyclin D2 Antibody (A-1) is a mouse monoclonal IgG2b antibody engineered to detect full-length human cyclin D2, encompassing amino acids 1-289. Cyclin D2, also referred to as Ccnd2, cD2, Vin1, and Vin-1, is a crucial regulator of the cell cycle, primarily involved in the transition from the G1 phase to the S phase by forming complexes with cyclin-dependent kinases Cdk4 and Cdk6. This interaction leads to the phosphorylation of the retinoblastoma (Rb) protein, resulting in the activation of E2F transcription factors that drive DNA synthesis and cell proliferation. Structurally, cyclin D2 contains a conserved cyclin box domain essential for its binding to Cdks, and undergoes significant post-translational modifications that regulate function and stability. Phosphorylation of cyclin D2 modulates activity and interactions, while ubiquitination targets cyclin D2 for proteasomal degradation, ensuring precise control of cell cycle progression. These modifications are vital for maintaining normal cellular growth and preventing uncontrolled proliferation, which is a hallmark of cancer. Anti-cyclin D2 antibody (A-1) is raised against the full-length human cyclin D2 protein and is optimized for the detection of cyclin D2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cyclin D2 monoclonal antibody (A-1) offers high specificity and sensitivity, making cyclin D2 (A-1) antibody an invaluable tool for researchers studying cell cycle dynamics, oncogenesis, and the molecular mechanisms underlying various cancers. By facilitating the accurate measurement and analysis of cyclin D2 and its post-translational modifications, anti-cyclin D2 antibody (A-1) supports advanced research in cell biology and therapeutic development aimed at targeting dysregulated cell cycle pathways in cancer.

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cyclin D2 Antibody (A-1) References:

1. Early induction of cyclin D2 expression in phorbol ester-responsive B-1 lymphocytes.  |  Tanguay, DA., et al. 1999. J Exp Med. 189: 1685-90. PMID: 10359571
2. Direct trans-activation of the human cyclin D2 gene by the oncogene product Tax of human T-cell leukemia virus type I.  |  Huang, Y., et al. 2001. Oncogene. 20: 1094-102. PMID: 11314046
3. The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells.  |  Kehn, K., et al. 2004. Retrovirology. 1: 6. PMID: 15169570
4. 17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression.  |  Kanda, N. and Watanabe, S. 2004. J Invest Dermatol. 123: 319-28. PMID: 15245432
5. Phosphatidylinositol 3-kinase is required for the transcriptional activation of cyclin D2 in BCR activated primary mouse B lymphocytes.  |  Glassford, J., et al. 2005. Eur J Immunol. 35: 2748-61. PMID: 16114097
6. Evidence of a role for the novel zinc-finger transcription factor ZKSCAN3 in modulating Cyclin D2 expression in multiple myeloma.  |  Yang, L., et al. 2011. Oncogene. 30: 1329-40. PMID: 21057542
7. Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channels.  |  Salpeter, SJ., et al. 2011. Endocrinology. 152: 2589-98. PMID: 21521747
8. Cyclin D2 is a critical mediator of exercise-induced cardiac hypertrophy.  |  Luckey, SW., et al. 2017. Exp Biol Med (Maywood). 242: 1820-1830. PMID: 28901173
9. Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2.  |  Pei, Y., et al. 2018. J Virol. 92: PMID: 29997218
10. Functional analysis of the human cyclin D2 and cyclin D3 promoters.  |  Brooks, AR., et al. 1996. J Biol Chem. 271: 9090-9. PMID: 8621559

The preferred cyclin D1 antibody is cyclin D1 Antibody (DCS-6): sc-20044.