CWC15 Antibody (H-1): sc-390450

CWC15 Antibody (H-1) is a mouse monoclonal IgA antibody that detects CWC15 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CWC15 antibody (H-1) is available as the non-conjugated form. CWC15 protein, also known as CWC15 spliceosome-associated protein, ORF5, Cwf15, C11orf5, or HSPC14, consists of 229 amino acids and plays a crucial role in pre-mRNA splicing, a fundamental process in gene expression that ensures correct maturation of messenger RNA. CWC15 protein is primarily located in the nucleus, where CWC15 (H-1) antibody can detect its presence in the spliceosome complex, which is essential for removing introns from pre-mRNA transcripts. Proper functioning of CWC15 is vital for maintaining cellular homeostasis and regulating gene expression, as errors in splicing can lead to various diseases, including cancer and genetic disorders. CWC15 gene is situated on human chromosome 11q21, a region known for its dense association with numerous genes linked to various diseases, including ataxia-telangiectasia and several blood disorders. Using anti-CWC15 antibody (H-1) in research can provide valuable insights into RNA processing mechanisms and their implications in health and disease.

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CWC15 Antibody (H-1) References:

1. The 11q terminal deletion disorder: a prospective study of 110 cases.  |  Grossfeld, PD., et al. 2004. Am J Med Genet A. 129A: 51-61. PMID: 15266616
2. Human chromosome 11 DNA sequence and analysis including novel gene identification.  |  Taylor, TD., et al. 2006. Nature. 440: 497-500. PMID: 16554811
3. KCNQ1 K+ channel-mediated cardiac channelopathies.  |  Loussouarn, G., et al. 2006. Methods Mol Biol. 337: 167-83. PMID: 16929947
4. Skipping of Exon 1 in the KCNQ1 gene causes Jervell and Lange-Nielsen syndrome.  |  Zehelein, J., et al. 2006. J Biol Chem. 281: 35397-403. PMID: 16987820
5. Beta-thalassaemia and sickle cell anaemia as paradigms of hypercoagulability.  |  Ataga, KI., et al. 2007. Br J Haematol. 139: 3-13. PMID: 17854302
6. The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3.  |  Berger, AC., et al. 2007. J Cell Sci. 120: 3640-52. PMID: 17895371
7. Wilms tumour: prognostic factors, staging, therapy and late effects.  |  Kaste, SC., et al. 2008. Pediatr Radiol. 38: 2-17. PMID: 18026723
8. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.  |  Lee, JH. and Paull, TT. 2007. Oncogene. 26: 7741-8. PMID: 18066086
9. Targeted cancer therapies based on the inhibition of DNA strand break repair.  |  O'Connor, MJ., et al. 2007. Oncogene. 26: 7816-24. PMID: 18066095

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CWC15 Antibody (H-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CWC15 Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CWC15 Antibody (H-1) Specifications

Alternate Product Name: CWC15

Product Clone Name: H-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA

Amino Acids: 47-60

Epitope Target: CWC15

Epitope Species: human

Product Reactivity/Detection: CWC15

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgA in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CWC15 Antibody (H-1): P: Blocking Peptide