CUZD1 Antibody (E-10): sc-514578
- CUZD1 Antibody (E-10) is a mouse monoclonal IgG2a κ CUZD1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 328-412 mapping within an internal region of CUZD1 of human origin
- CUZD1 Antibody (E-10) is recommended for detection of CUZD1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CUZD1 Antibody (E-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CUZD1 Antibody (E-10) for WB applications. These reagents are now offered in bundles with CUZD1 Antibody (E-10) (see ordering information below).
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SEE ALSO...
CUZD1 Antibody (E-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects CUZD1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CUZD1 antibody (E-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CUZD1, also known as CUB and zona pellucida-like domains 1 or ERG-1 (estrogen regulated gene 1), is a 607 amino acid single-pass type I membrane protein characterized by the presence of two CUB domains and a zona pellucida domain. CUZD1 is predominantly expressed in the pancreas and ovarian epithelium, with significantly elevated levels observed in ovarian tumors, highlighting a potential role in cancer biology. CUZD1 inhibits cell attachment and proliferation of ovarian cancer cells, thereby influencing cell motility and interactions with the extracellular matrix, which are critical processes in tumor progression and metastasis. The gene encoding CUZD1 is located on human chromosome 10, which contains approximately 800 genes, including important tumor suppressor genes such as PTEN, linked to Cowden syndrome, and ERCC6, associated with DNA repair and Cockayne syndrome. Understanding CUZD1′s function and interactions within the cellular environment is essential for elucidating a role in cancer and developing targeted therapies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CUZD1 Antibody (E-10) References:
- Report of the third international workshop on human chromosome 10 mapping and sequencing 1999. | Deloukas, P., et al. 2000. Cytogenet Cell Genet. 90: 1-12. PMID: 11060438
- Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane-associated protein, UO-44. | Leong, CT., et al. 2004. Oncogene. 23: 5707-18. PMID: 15184879
- Identification and characterization of novel and unknown mouse epididymis-specific genes by complementary DNA microarray technology. | Yamazaki, K., et al. 2006. Biol Reprod. 75: 462-8. PMID: 16707773
- Silencing expression of UO-44 (CUZD1) using small interfering RNA sensitizes human ovarian cancer cells to cisplatin in vitro. | Leong, CT., et al. 2007. Oncogene. 26: 870-80. PMID: 16862170
- Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation. | Teresi, RE., et al. 2007. Am J Hum Genet. 81: 756-67. PMID: 17847000
- The origins of human embryonic stem cells: a biological conundrum. | Brink, TC., et al. 2008. Cells Tissues Organs. 188: 9-22. PMID: 18160822
- PTEN: a new guardian of the genome. | Yin, Y. and Shen, WH. 2008. Oncogene. 27: 5443-53. PMID: 18794879
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CUZD1 Antibody (E-10) | sc-514578 | 200 µg/ml | $322.00 | |||
CUZD1 Antibody (E-10): m-IgGκ BP-HRP Bundle | sc-524778 | 200 µg Ab, 40 µg BP | $361.00 | |||
CUZD1 Antibody (E-10): m-IgG2a BP-HRP Bundle | sc-546174 | 200 µg Ab; 10 µg BP | $361.00 | |||
CUZD1 Antibody (E-10) AC | sc-514578 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CUZD1 Antibody (E-10) HRP | sc-514578 HRP | 200 µg/ml | $322.00 | |||
CUZD1 Antibody (E-10) FITC | sc-514578 FITC | 200 µg/ml | $336.00 | |||
CUZD1 Antibody (E-10) PE | sc-514578 PE | 200 µg/ml | $349.00 | |||
CUZD1 Antibody (E-10) Alexa Fluor® 488 | sc-514578 AF488 | 200 µg/ml | $364.00 | |||
CUZD1 Antibody (E-10) Alexa Fluor® 546 | sc-514578 AF546 | 200 µg/ml | $364.00 | |||
CUZD1 Antibody (E-10) Alexa Fluor® 594 | sc-514578 AF594 | 200 µg/ml | $364.00 | |||
CUZD1 Antibody (E-10) Alexa Fluor® 647 | sc-514578 AF647 | 200 µg/ml | $364.00 | |||
CUZD1 Antibody (E-10) Alexa Fluor® 680 | sc-514578 AF680 | 200 µg/ml | $364.00 | |||
CUZD1 Antibody (E-10) Alexa Fluor® 790 | sc-514578 AF790 | 200 µg/ml | $364.00 |