CUTC Antibody (E-1): sc-515505

CUTC Antibody (E-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects CUTC protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CUTC (E-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CUTC protein, also known as CGI-32, is a 273 amino acid protein that plays a crucial role in copper homeostasis, acting as a transporter that facilitates the movement of copper ions across cellular membranes. This function is vital because copper is an essential micronutrient that serves as a co-factor for numerous enzymes involved in critical biological processes, including energy production and antioxidant defense. However, due to the high toxicity of copper, copper metabolism must be tightly regulated; dysregulation can lead to severe health issues such as Menkes disease, characterized by copper deficiency, or Wilson disease, which results in copper accumulation and associated organ damage. CUTC gene is located on human chromosome 10, a region that also harbors the important tumor suppressor gene PTEN, which is implicated in Cowden syndrome when mutated. Understanding the interactions and regulatory mechanisms of CUTC protein is essential for elucidating its role in both normal physiology and disease states.

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CUTC Antibody (E-1) References:

1. Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC.  |  Li, J., et al. 2005. Biochem Biophys Res Commun. 337: 179-83. PMID: 16182249
2. Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation.  |  Teresi, RE., et al. 2007. Am J Hum Genet. 81: 756-67. PMID: 17847000
3. PTEN: a new guardian of the genome.  |  Yin, Y. and Shen, WH. 2008. Oncogene. 27: 5443-53. PMID: 18794879
4. Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site.  |  Li, Y., et al. 2010. J Struct Biol. 169: 399-405. PMID: 19878721
5. Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome.  |  Laugel, V., et al. 2010. Hum Mutat. 31: 113-26. PMID: 19894250
6. Gut microbes impact stroke severity via the trimethylamine N-oxide pathway.  |  Zhu, W., et al. 2021. Cell Host Microbe. 29: 1199-1208.e5. PMID: 34139173
7. Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota.  |  Ma, SR., et al. 2022. Signal Transduct Target Ther. 7: 207. PMID: 35794102
8. The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer.  |  Mirji, G., et al. 2022. Sci Immunol. 7: eabn0704. PMID: 36083892
9. Gut Microbiota-Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms.  |  Benson, TW., et al. 2023. Circulation. 147: 1079-1096. PMID: 37011073
10. Dysfunction of cecal microbiota and CutC activity in mice mediating diarrhea with kidney-yang deficiency syndrome.  |  Guo, M., et al. 2024. Front Microbiol. 15: 1354823. PMID: 38500584
11. Elevated CUTC: A prognostic indicator of adverse outcomes in clear cell renal carcinoma.  |  Ran, L., et al. 2024. Asian J Surg.. PMID: 39550257
12. Identification of cutC and cutF (nlpE) genes involved in copper tolerance in Escherichia coli.  |  Gupta, SD., et al. 1995. J Bacteriol. 177: 4207-15. PMID: 7635807

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CUTC Antibody (E-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CUTC Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CUTC Antibody (E-1) Specifications

Alternate Product Name: CUTC

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 24-126

Epitope Target: CUTC

Epitope Species: human

Product Reactivity/Detection: CUTC

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CUTC Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin