CUL-1 Antibody (19): sc-135874
- CUL-1 Antibody (19) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against amino acids 56-246 of CUL-1 of mouse origin
- recommended for detection of CUL-1 of mouse, rat, human and canine origin by WB and IP
- See CUL-1 (D-5): sc-17775 for CUL-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CUL-1 Antibody (19). This work is in progress.
CUL-1 Antibody (19) is a mouse monoclonal IgG1 antibody that detects CUL-1 in mouse, rat, human, and canine samples through applications such as western blotting (WB) and immunoprecipitation (IP). CUL-1 plays a crucial role in protein degradation regulation, specifically through involvement in the E3 ubiquitin ligase complex known as SCF (Skp1/CUL-1/F-box protein complex). This complex is essential for selective targeting of proteins for ubiquitin-mediated proteolysis, which maintains cellular homeostasis and regulates the cell cycle. Through mediating the degradation of key cell cycle proteins such as cyclin D, p21, and cyclin E, CUL-1 ensures proper cell cycle progression and prevents uncontrolled cell proliferation, which can lead to tumorigenesis. CUL-1′s interaction with various F-box proteins allows for substrate specificity, highlighting importance in cellular signaling pathways. Formation of complexes with other cullins, such as CUL-2 and CUL-3, further emphasizes CUL-1′s role in diverse cellular processes, making anti-CUL-1 antibody (19) an invaluable tool for researchers studying protein regulation and degradation mechanisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CUL-1 Antibody (19) | sc-135874 | 50 µg/0.5 ml | $322.00 |