CTRP1 Antibody (2E7): sc-81943

CTRP1 Antibody (2E7) is a mouse monoclonal IgG2a kappa light chain antibody that detects CTRP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CTRP1 antibody (2E7) is available as a non-conjugated format. CTRP1, also known as Complement C1q tumor necrosis factor-related protein 1 precursor, G protein-coupled receptor-interacting protein, and GIP, is a 281 amino acid protein encoded by the human gene C1QTN1. As a member of the CTRP superfamily, CTRP1 plays a crucial role in metabolic regulation and is predominantly expressed in adipose tissues, particularly in the context of obesity, as seen in obese Zucker diabetic fatty (fa/fa) rats. CTRP1 features a unique structure that includes an N-terminal signal peptide, a variable region, a collagen repeat domain, and a C-terminal globular domain, which are essential for biological activity and interactions. CTRP1 expression is upregulated by proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-1 beta, linking CTRP1 to low-grade chronic inflammation in adipose tissues. This connection underscores CTRP1′s importance in metabolic disorders and potential as a therapeutic target, making anti-CTRP1 antibody (2E7) a valuable tool for researchers studying obesity and related inflammatory conditions.

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CTRP1 Antibody (2E7) References:

1. Short-term effects of fish oil treatment on urinary excretion of high- and low-molecular weight proteins in patients with IgA nephropathy.  |  Branten, AJ., et al. 2002. Clin Nephrol. 58: 267-74. PMID: 12400841
2. IgA nephropathy and hodgkin's disease: a rare coincidence. Case report and literature review.  |  Bergmann, J., et al. 2005. Am J Kidney Dis. 45: e16-9. PMID: 15696435
3. Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue.  |  Kim, KY., et al. 2006. FEBS Lett. 580: 3953-60. PMID: 16806199
4. IgA nephropathy associated with Hodgkin's disease in children: a case report, literature review and urinary proteome analysis.  |  Khositseth, S., et al. 2007. Pediatr Nephrol. 22: 541-6. PMID: 17143626
5. A novel adipokine CTRP1 stimulates aldosterone production.  |  Jeon, JH., et al. 2008. FASEB J. 22: 1502-11. PMID: 18171693
6. Increased excretion of tumor necrosis factor alpha and interleukin 1 beta in urine from patients with IgA nephropathy and Schönlein-Henoch purpura.  |  Wu, TH., et al. 1996. Nephron. 74: 79-88. PMID: 8883024

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CTRP1 Antibody (2E7) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-CTRP1 Antibody (2E7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CTRP1 Antibody (2E7) Specifications

Alternate Product Name: CTRP1

Product Clone Name: 2E7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 26-282

Epitope Target: CTRP1

Epitope Species: human

Product Reactivity/Detection: CTRP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for CTRP1 Antibody (2E7): N/A