Crry Antibody (TLD-1C11): sc-53530
- Crry Antibody (TLD-1C11) is a mouse monoclonal IgG*** Crry antibody provided at 200 µg/ml
- raised against cultured microglial cells of rat origin
- Crry Antibody (TLD-1C11) is recommended for detection of Crry of mouse and rat origin by WB, IF, IHC(P) and FCM
- Anti-Crry Antibody (TLD-1C11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Crry Antibody (TLD-1C11). This work is in progress.
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Crry Antibody (TLD-1C11) is a mouse monoclonal IgG antibody that detects Crry protein of mouse and rat origin by western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Crry (TLD-1C11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Crry protein, also known as complement receptor-related gene Y, plays a crucial role in regulating the complement system, which protects the body from inflammation-induced damage. Crry (TLD-1C11) monoclonal antibody functions as a complement regulator that inhibits complement proteins C3 and C4 convertases, thereby preventing unwanted marking of host cells for destruction. This regulatory function maintains tissue homeostasis and modulates immune responses, especially in kidneys, where Crry helps mitigate renal interstitial disease caused by proteinuria. Crry serves as a functional ortholog of human decay-accelerating factor (DAF) and membrane cofactor protein (MCP), highlighting significance in both murine and human health. Manipulation of Crry may offer therapeutic avenues for conditions such as traumatic brain injury or stroke, while deletion of the Crry gene has been implicated in reproductive issues, including miscarriages.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Crry Antibody (TLD-1C11) References:
- Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor. | Molina, H., et al. 2002. Blood. 100: 4544-9. PMID: 12393518
- The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy. | Aslam, M., et al. 2003. J Mol Biol. 329: 525-50. PMID: 12767833
- The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction. | Lee, YL., et al. 2004. J Biol Chem. 279: 12763-8. PMID: 14699127
- Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis. | Mühlfeld, AS., et al. 2004. Kidney Int. 65: 1214-23. PMID: 15086460
- Tumor-specific inhibition of membrane-bound complement regulatory protein Crry with bispecific monoclonal antibodies prevents tumor outgrowth in a rat colorectal cancer lung metastases model. | Gelderman, KA., et al. 2004. Cancer Res. 64: 4366-72. PMID: 15205353
- Mouse complement receptor-related gene y/p65-neutralized tumor vaccine induces antitumor activity in vivo. | Ohta, R., et al. 2004. J Immunol. 173: 205-13. PMID: 15210776
- The role of rat Crry, a complement regulatory protein, in proliferation of thymocytes. | Antic Stankovic, J., et al. 2004. Life Sci. 75: 3053-62. PMID: 15474557
- Complement inhibitors targeted to the proximal tubule prevent injury in experimental nephrotic syndrome and demonstrate a key role for C5b-9. | He, C., et al. 2005. J Immunol. 174: 5750-7. PMID: 15843577
- Complement regulatory protein Crry/p65-mediated signaling in T lymphocytes: role of its cytoplasmic domain and partitioning into lipid rafts. | Jiménez-Periañez, A., et al. 2005. J Leukoc Biol. 78: 1386-96. PMID: 16301324
- The murine complement receptor gene family. IV. Alternative splicing of Cr2 gene transcripts predicts two distinct gene products that share homologous domains with both human CR2 and CR1. | Kurtz, CB., et al. 1990. J Immunol. 144: 3581-91. PMID: 2139460
- Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement system. | Zhu, XC., et al. 2022. Neural Regen Res. 17: 1841-1849. PMID: 35017447
- Expression dynamics of Crry at the implantation sites in normal pregnancy and response against miscarriage induction. | Kuniyoshi, N., et al. 2023. J Vet Med Sci. 85: 92-98. PMID: 36450590
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Crry Antibody (TLD-1C11) | sc-53530 | 200 µg/ml | $322.00 | |||
Crry Antibody (TLD-1C11) AC | sc-53530 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Crry Antibody (TLD-1C11) HRP | sc-53530 HRP | 200 µg/ml | $322.00 | |||
Crry Antibody (TLD-1C11) FITC | sc-53530 FITC | 200 µg/ml | $336.00 | |||
Crry Antibody (TLD-1C11) PE | sc-53530 PE | 200 µg/ml | $349.00 | |||
Crry Antibody (TLD-1C11) Alexa Fluor® 488 | sc-53530 AF488 | 200 µg/ml | $364.00 | |||
Crry Antibody (TLD-1C11) Alexa Fluor® 546 | sc-53530 AF546 | 200 µg/ml | $364.00 | |||
Crry Antibody (TLD-1C11) Alexa Fluor® 594 | sc-53530 AF594 | 200 µg/ml | $364.00 | |||
Crry Antibody (TLD-1C11) Alexa Fluor® 647 | sc-53530 AF647 | 200 µg/ml | $364.00 | |||
Crry Antibody (TLD-1C11) Alexa Fluor® 680 | sc-53530 AF680 | 200 µg/ml | $364.00 | |||
Crry Antibody (TLD-1C11) Alexa Fluor® 790 | sc-53530 AF790 | 200 µg/ml | $364.00 |