CRP Antibody (26D7): sc-69770

CRP Antibody (26D7) is a mouse monoclonal IgG1 antibody that detects CRP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CRP antibody (26D7) is available as the non-conjugated form. C-reactive protein (CRP) is a crucial acute-phase protein produced primarily by liver epithelial cells in response to inflammation, and CRP levels can rise dramatically during acute inflammatory states, making CRP an important biomarker for various diseases. CRP′s pentameric structure allows binding to phosphocholine, a component found on the surface of damaged cells and pathogens, facilitating their recognition and clearance by the immune system. This binding is essential for opsonization, a process that enhances phagocytosis by immune cells, thereby playing a vital role in the host defense mechanism. Additionally, CRP expression is influenced by various cytokines, with interleukin-6 being the primary inducer, highlighting CRP′s involvement in the inflammatory response. Anti-CRP antibody (26D7) enables valuable insights into CRP′s role in inflammation and potential as a therapeutic target.

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CRP Antibody (26D7) References:

1. Complement-dependent acute-phase expression of C-reactive protein and serum amyloid P-component.  |  Szalai, AJ., et al. 2000. J Immunol. 165: 1030-5. PMID: 10878380
2. Role of STAT3 and C/EBP in cytokine-dependent expression of the mouse serum amyloid P-component (SAP) and C-reactive protein (CRP) genes.  |  Ochrietor, JD., et al. 2000. Cytokine. 12: 888-99. PMID: 10880233
3. Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis.  |  Bharadwaj, D., et al. 2001. J Immunol. 166: 6735-41. PMID: 11359830
4. C-reactive protein beyond biomarker of inflammation in metabolic syndrome.  |  Horiuchi, M. and Mogi, M. 2011. Hypertension. 57: 672-3. PMID: 21357270
5. Maternal C-reactive protein and schizophrenia.  |  Selten, JP. and van Os, J. 2015. Am J Psychiatry. 172: 200. PMID: 25640933
6. Bioanalytical advances in assays for C-reactive protein.  |  Vashist, SK., et al. 2016. Biotechnol Adv. 34: 272-90. PMID: 26717866
7. Role of C-reactive Protein in Acute Appendicitis.  |  Ghimire, R., et al. 2016. Kathmandu Univ Med J (KUMJ). 14: 130-133. PMID: 28166068
8. Purification of recombinant C-reactive protein mutants.  |  Thirumalai, A., et al. 2017. J Immunol Methods. 443: 26-32. PMID: 28167277
9. Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes.  |  Alles, VV., et al. 1994. Blood. 84: 3483-93. PMID: 7949102
10. Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites.  |  Introna, M., et al. 1996. Blood. 87: 1862-72. PMID: 8634434
11. Acute phase proteins in salmonids: evolutionary analyses and acute phase response.  |  Jensen, LE., et al. 1997. J Immunol. 158: 384-92. PMID: 8977214
12. Testosterone and IL-6 requirements for human C-reactive protein gene expression in transgenic mice.  |  Szalai, AJ., et al. 1998. J Immunol. 160: 5294-9. PMID: 9605127

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CRP Antibody (26D7) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-CRP Antibody (26D7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CRP Antibody (26D7) Specifications

Alternate Product Name: CRP

Product Clone Name: 26D7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: CRP

Epitope Species: human

Product Reactivity/Detection: CRP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin, 1% glycerol and < 0.1% stabilizer protein

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for CRP Antibody (26D7): N/A