CRMP-2 Antibody (1B1): sc-101348
- CRMP-2 Antibody (1B1) is a mouse monoclonal IgG2a CRMP-2 antibody, cited in 2 publications, provided at 100 µg/ml
- raised against a synthetic peptide derived from the C-terminus of CRMP-2 of human origin
- recommended for detection of CRMP-2 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CRMP-2 Antibody (1B1). This work is in progress.
CRMP-2 Antibody (1B1) is a mouse monoclonal IgG2a antibody that detects CRMP-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-CRMP-2 antibody (1B1) is available as the non-conjugated format. The collapsin response mediator protein 2 (CRMP-2) plays a crucial role in neuronal development and function, particularly in axonal growth and guidance, which are essential for proper neural network formation and repair. CRMP-2 is primarily located in the cytoplasm and translocates to the growth cone during axonal development, where CRMP-2 interacts with various signaling pathways that regulate cytoskeletal dynamics. Proper localization and function of CRMP-2 are vital for neuronal plasticity and response to external cues, such as the axon guidance molecule Semaphorin 3A, which influences neuronal pathfinding. The human CRMP-2 gene is located on chromosome 8p21.2, a region associated with schizophrenia, highlighting CRMP-2′s importance in both normal brain function and neuropsychiatric disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CRMP-2 Antibody (1B1) References:
- Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene. | Kitamura, K., et al. 1999. DNA Res. 6: 291-7. PMID: 10574455
- Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. | Gu, Y., et al. 2000. Biochemistry. 39: 4267-75. PMID: 10757975
- The human dihydropyrimidinase-related protein 2 gene on chromosome 8p21 is associated with paranoid-type schizophrenia. | Nakata, K., et al. 2003. Biol Psychiatry. 53: 571-6. PMID: 12679234
- Subcellular localization of collapsin response mediator proteins to lipid rafts. | Rosslenbroich, V., et al. 2003. Biochem Biophys Res Commun. 305: 392-9. PMID: 12745088
- Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons. | Quach, TT., et al. 2004. Mol Cell Neurosci. 25: 433-43. PMID: 15033171
- Induction of CRMP-2 by GDNF and analysis of the CRMP-2 promoter region. | Kodama, Y., et al. 2004. Biochem Biophys Res Commun. 320: 108-15. PMID: 15207709
- Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia. | Hong, LE., et al. 2005. Am J Med Genet B Neuropsychiatr Genet. 136B: 8-11. PMID: 15858820
- Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β. | Ou, Y., et al. 2012. PLoS One. 7: e48773. PMID: 23185275
- Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions. | Moutal, A., et al. 2019. Mol Neurobiol. 56: 6736-6755. PMID: 30915713
- Druggability of CRMP2 for Neurodegenerative Diseases. | Khanna, R., et al. 2020. ACS Chem Neurosci. 11: 2492-2505. PMID: 32693579
- Spastin Interacts with CRMP2 to Regulate Neurite Outgrowth by Controlling Microtubule Dynamics through Phosphorylation Modifications. | Li, S., et al. 2021. CNS Neurol Disord Drug Targets. 20: 249-265. PMID: 33109053
- Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats. | Rahamim, N., et al. 2024. Int J Mol Sci. 25: PMID: 38791516
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRMP-2 Antibody (1B1) | sc-101348 | 100 µg/ml | $339.00 |