CRLF3 Antibody (D-10): sc-398388

CRLF3 Antibody (D-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects CRLF3 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CRLF3 (D-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CRLF3, also known as cytokine receptor-like factor 3, plays a crucial role in cellular signaling and regulates the G0/G1 phase of the cell cycle, essential for controlling cell proliferation and maintaining normal cellular function. This regulation is particularly important in cancer, as dysregulation of the cell cycle can lead to uncontrolled cell growth and tumor development. CRLF3 is expressed in various pathological conditions, including actinic keratosis and squamous cell carcinoma, highlighting potential as a biomarker for these diseases. The gene encoding CRLF3 is located on human chromosome 17, a region associated with key tumor suppressor genes such as p53 and BRCA1, both critical in maintaining genomic stability and preventing cancer. Understanding CRLF3 function in cellular processes can provide valuable insights into cancer biology and therapeutic targeting.

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CRLF3 Antibody (D-10) References:

1. p53 website and analysis of p53 gene mutations in human cancer: forging a link between epidemiology and carcinogenesis.  |  Soussi, T., et al. 2000. Hum Mutat. 15: 105-13. PMID: 10612830
2. Distinct pattern of p53 phosphorylation in human tumors.  |  Minamoto, T., et al. 2001. Oncogene. 20: 3341-7. PMID: 11423984
3. Three primary malignancies related to BRCA mutation successively occurring in a BRCA1 185delAG mutation carrier.  |  Piura, B., et al. 2001. Eur J Obstet Gynecol Reprod Biol. 97: 241-4. PMID: 11451557
4. Closing in on a breast cancer gene on chromosome 17q.  |  Hall, JM., et al. 1992. Am J Hum Genet. 50: 1235-42. PMID: 1598904
5. Identification of dysregulated genes in cutaneous squamous cell carcinoma.  |  Dang, C., et al. 2006. Oncol Rep. 16: 513-9. PMID: 16865251
6. Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression.  |  Yang, F., et al. 2009. Int J Biochem Cell Biol. 41: 2240-50. PMID: 19427400
7. A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene.  |  Varley, JM., et al. 1997. Oncogene. 14: 865-71. PMID: 9047394
8. The Li-Fraumeni syndrome: an inherited susceptibility to cancer.  |  Evans, SC. and Lozano, G. 1997. Mol Med Today. 3: 390-5. PMID: 9302689
9. Loss of heterozygosity for defined regions on chromosomes 3, 11 and 17 in carcinomas of the uterine cervix.  |  Kersemaekers, AM., et al. 1998. Br J Cancer. 77: 192-200. PMID: 9460988

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CRLF3 Antibody (D-10) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-CRLF3 Antibody (D-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CRLF3 Antibody (D-10) Specifications

Alternate Product Name: CRLF3

Product Clone Name: D-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 3-242

Epitope Target: CRLF3

Epitope Species: human

Product Reactivity/Detection: CRLF3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for CRLF3 Antibody (D-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin