CRF-BP Antibody (G-2): sc-365427
- CRF-BP Antibody (G-2) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 299-322 at the C-terminus of CRF-BP of human origin
- recommended for detection of CRF-BP of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CRF-BP Antibody (G-2). This work is in progress.
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CRF-BP Antibody (G-2) is a mouse monoclonal IgM antibody that detects CRF-BP in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CRF-BP, also known as corticotropin-releasing hormone-binding protein, plays a crucial role in regulating the activity of corticotropin-releasing hormone (CRH) by binding to it and preventing its interaction with the CRH receptor. This interaction is particularly important as it helps modulate the hypothalamic-pituitary-adrenal (HPA) axis, which is essential for the body′s response to stress. By inactivating CRH, CRF-BP serves as a protective mechanism against excessive stimulation of the pituitary-adrenal system, especially during pregnancy, where inappropriate levels of CRH could lead to complications. CRF-BP is primarily produced in the liver and is secreted into the bloodstream, where CRF-BP circulates and binds to CRH, thus influencing CRH bioavailability and activity. The gene encoding CRF-BP is located on human chromosome 5q11.2-q13.3, and understanding CRF-BP function and regulation is vital for elucidating the complex hormonal interactions that govern stress responses and reproductive health. Anti-CRF-BP antibody (G-2) is an invaluable tool for researchers studying these critical biological processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRF-BP Antibody (G-2) | sc-365427 | 200 µg/ml | $322.00 | |||
CRF-BP (G-2) Neutralizing Peptide | sc-365427 P | 100 µg/0.5 ml | $69.00 |