CRF-BP Antibody (C-8): sc-365975
- CRF-BP Antibody (C-8) is a mouse monoclonal IgG2b κ CRF-BP antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 299-322 at the C-terminus of CRF-BP of human origin
- CRF-BP Antibody (C-8) is recommended for detection of CRF-BP of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-CRF-BP Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for CRF-BP Antibody (C-8) for WB and IHC(P) applications. This reagent is now offered in a bundle with CRF-BP Antibody (C-8) (see ordering information below).
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CRF-BP Antibody (C-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects CRF-BP of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CRF-BP (C-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CRF-BP plays a crucial role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, which is essential for the body′s response to stress. By binding to corticotropin-releasing hormone (CRH), CRF-BP inactivates this hormone, thereby preventing excessive stimulation of the pituitary gland and subsequent adrenal hormone release. This regulatory mechanism is particularly important during pregnancy, where CRF-BP helps to modulate the levels of CRH produced in the placenta, ensuring a balanced response to stressors. The gene encoding CRF-BP is located on human chromosome 5q11.2-q13.3, and CRF-BP expression is vital for maintaining homeostasis in the face of physiological challenges.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CRF-BP Antibody (C-8) References:
- Performance-enhancing effects of CRF-BP ligand inhibitors. | Zorrilla, EP., et al. 2001. Neuroreport. 12: 1231-4. PMID: 11338197
- Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. | Potter, E., et al. 1991. Nature. 349: 423-6. PMID: 1846945
- Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. | Robinson, BG., et al. 1988. Proc Natl Acad Sci U S A. 85: 5244-8. PMID: 2839838
- Human corticotropin releasing hormone gene is located on the long arm of chromosome 8. | Arbiser, JL., et al. 1988. Cytogenet Cell Genet. 47: 113-6. PMID: 3259914
- Mapping the human corticotropin releasing hormone binding protein gene (CRHBP) to the long arm of chromosome 5 (5q11.2-q13.3). | Vamvakopoulos, NC., et al. 1995. Genomics. 25: 325-7. PMID: 7774945
- Corticotropin releasing factor binding protein (CRF-BP) is expressed in neuronal and astrocytic cells. | Behan, DP., et al. 1995. Brain Res. 698: 259-64. PMID: 8581494
- Urocortin interaction with corticotropin-releasing factor (CRF) binding protein (CRF-BP): a novel mechanism for elevating 'free' CRF levels in human brain. | Behan, DP., et al. 1996. Brain Res. 725: 263-7. PMID: 8836534
- Corticotropin-releasing factor (CRF), CRF-binding protein (CRF-BP), and CRF/CRF-BP complex in Alzheimer's disease and control postmortem human brain. | Behan, DP., et al. 1997. J Neurochem. 68: 2053-60. PMID: 9109532
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRF-BP Antibody (C-8) | sc-365975 | 200 µg/ml | $316.00 | |||
CRF-BP Antibody (C-8): m-IgG2b BP-HRP Bundle | sc-548731 | 200 µg Ab; 10 µg BP | $354.00 | |||
CRF-BP Antibody (C-8) AC | sc-365975 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CRF-BP Antibody (C-8) HRP | sc-365975 HRP | 200 µg/ml | $316.00 | |||
CRF-BP Antibody (C-8) FITC | sc-365975 FITC | 200 µg/ml | $330.00 | |||
CRF-BP Antibody (C-8) PE | sc-365975 PE | 200 µg/ml | $343.00 | |||
CRF-BP Antibody (C-8) Alexa Fluor® 488 | sc-365975 AF488 | 200 µg/ml | $357.00 | |||
CRF-BP Antibody (C-8) Alexa Fluor® 546 | sc-365975 AF546 | 200 µg/ml | $357.00 | |||
CRF-BP Antibody (C-8) Alexa Fluor® 594 | sc-365975 AF594 | 200 µg/ml | $357.00 | |||
CRF-BP Antibody (C-8) Alexa Fluor® 647 | sc-365975 AF647 | 200 µg/ml | $357.00 | |||
CRF-BP Antibody (C-8) Alexa Fluor® 680 | sc-365975 AF680 | 200 µg/ml | $357.00 | |||
CRF-BP Antibody (C-8) Alexa Fluor® 790 | sc-365975 AF790 | 200 µg/ml | $357.00 | |||
CRF-BP (C-8) Neutralizing Peptide | sc-365975 P | 100 µg/0.5 ml | $68.00 |