CRELD2 Antibody (C-7): sc-271858

CRELD2 Antibody (C-7) is a mouse monoclonal IgG3 antibody that detects CRELD2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CRELD2, or cysteine-rich with EGF-like domains 2, is a 353 amino acid protein that plays a crucial role in various cellular processes, including cell adhesion and neural development, making CRELD2 essential for proper tissue formation and function. CRELD2 is primarily localized to the endoplasmic reticulum, where CRELD2 is secreted into the extracellular space, allowing interaction with other proteins, such as AChRα4, which may influence transport and function. The presence of two EGF-like domains and two FU domains in CRELD2 highlights structural complexity and potential for diverse interactions, which are vital for biological activities. Notably, human CRELD2 shares 69% amino acid identity with mouse CRELD2, indicating a conserved function across species, and multiple isoforms arise from alternative splicing, further expanding functional repertoire. The gene encoding CRELD2 is located on human chromosome 22, a region associated with several genetic disorders, including Phelan-McDermid syndrome and neurofibromatosis type 2, underscoring CRELD2′s importance in health and disease.

The preferred CRELD2 antibody is CRELD2 Antibody (A-8): sc-365168.