CPEB Antibody (G-6): sc-514688

CPEB Antibody (G-6) is a mouse monoclonal IgG3 kappa light chain antibody that detects CPEB protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CPEB antibody (G-6) is available as a non-conjugated monoclonal isotype antibody. CPEB (G-6) antibody recognizes a highly conserved RNA-binding protein that binds to the cytoplasmic polyadenylation element, influencing translational repression and mRNA localization. CPEB plays a crucial role in regulating messenger RNA translation, vital for various cellular processes, including cell-cycle progression and early developmental body plan establishment. This regulation is particularly important in oocyte maturation, where mRNA activation and repression are tightly controlled. CPEB is synthesized during oogenesis and accumulates in the oocyte, with degradation occurring through the proteasome pathway, likely involving ubiquitin-conjugated intermediates. Understanding CPEB function and regulatory mechanisms is essential for elucidating gene expression and developmental biology complexities, making CPEB (G-6) monoclonal antibody a valuable research tool.

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CPEB Antibody (G-6) References:

1. Maskin is a CPEB-associated factor that transiently interacts with elF-4E.  |  Stebbins-Boaz, B., et al. 1999. Mol Cell. 4: 1017-27. PMID: 10635326
2. CPEB proteins control two key steps in spermatogenesis in C. elegans.  |  Luitjens, C., et al. 2000. Genes Dev. 14: 2596-609. PMID: 11040214
3. CPEB, maskin, and cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell division.  |  Groisman, I., et al. 2000. Cell. 103: 435-47. PMID: 11081630
4. Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein.  |  Welk, JF., et al. 2001. Gene. 263: 113-20. PMID: 11223249
5. Translational control by CPEB: a means to the end.  |  Mendez, R. and Richter, JD. 2001. Nat Rev Mol Cell Biol. 2: 521-9. PMID: 11433366
6. Role of cdc2 kinase phosphorylation and conserved N-terminal proteolysis motifs in cytoplasmic polyadenylation-element-binding protein (CPEB) complex dissociation and degradation.  |  Thom, G., et al. 2003. Biochem J. 370: 91-100. PMID: 12401129
7. Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-dependent protein kinase II.  |  Atkins, CM., et al. 2004. J Neurosci. 24: 5193-201. PMID: 15175389
8. RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB.  |  Kim, JH. and Richter, JD. 2007. Genes Dev. 21: 2571-9. PMID: 17938241
9. CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation.  |  Burns, DM. and Richter, JD. 2008. Genes Dev. 22: 3449-60. PMID: 19141477
10. Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation.  |  Si, K., et al. 2010. Cell. 140: 421-35. PMID: 20144764
11. Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic polyadenylation element-binding protein CPEB.  |  Ogami, K., et al. 2014. Oncogene. 33: 55-64. PMID: 23178487
12. Reduction of Aspergillus niger Virulence in Apple Fruits by Deletion of the Catalase Gene cpeB.  |  Zhang, MK., et al. 2018. J Agric Food Chem. 66: 5401-5409. PMID: 29745230

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CPEB Antibody (G-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CPEB Antibody (G-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CPEB Antibody (G-6) Specifications

Alternate Product Name: CPEB

Product Clone Name: G-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 162-187

Epitope Target: CPEB

Epitope Species: human

Product Reactivity/Detection: CPEB long and short isoforms

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CPEB Antibody (G-6): P: Blocking Peptide, X: TransCruz Reagent