CPEB Activators
The class of CPEB Activators comprises a range of chemical compounds that indirectly influence the activity of Cytoplasmic polyadenylation element-binding protein 1. These chemicals do not directly interact with CPEB but rather modulate various signaling pathways and cellular processes that converge on the regulation of mRNA translation and stability, processes in which CPEB is a critical player. For instance, compounds like AICAR and Forskolin, which activate AMPK and PKA respectively, can affect the phosphorylation status of proteins involved in mRNA regulation, thereby influencing CPEB function.
Moreover, the involvement of CPEB in neuronal and synaptic functions links it to pathways regulated by calcium signaling and neurotransmitters. Calcium Ionophores like A23187 and neurotransmitter agonists like Glutamate can, therefore, impact neuronal pathways, indirectly modulating CPEB's activity in these contexts. Similarly, the modulation of the mTOR, MAPK/ERK, and JNK pathways by respective activators such as Rapamycin and Anisomycin can alter the cellular environment in a way that affects CPEB's role in mRNA translation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Activates AMPK, influencing mRNA translation and stability, processes regulated by CPEB. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, affecting protein synthesis pathways and potentially impacting CPEB's role in mRNA translation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates PKA, involved in phosphorylation of factors in mRNA translation, potentially affecting CPEB. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Increases intracellular calcium, modulating signaling pathways affecting CPEB-regulated mRNA translation. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
Increases intracellular cAMP, potentially influencing pathways modulating CPEB activity in mRNA regulation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Activates the MAPK/ERK pathway, potentially impacting CPEB function in mRNA translation. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
Activates NMDA receptor, may influence neuronal pathways where CPEB plays a role. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Specific inhibitor of MEK, indirectly affecting MAPK/ERK pathway and potentially CPEB function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K, affecting downstream signaling pathways and potentially impacting CPEB's role in mRNA regulation. | ||||||