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(-)-Cotinine is a major nicotine metabolite. (-)-Cotinine has been shown to activate a subpopulation of α3/ α6β2 nAChRs in monkey striatum. It has a long pharmacological half-life (15-19 hours) compared to that of nicotine (2-3 hours). (-)-Cotinine binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.
Buccafusco and Terry (2003) The potential role of cotinine in the cognitive and neuroprotective actions of nicotine. Life sci. 72 2931. Terry et al (2005) Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition. CNS Drug Rev. 11 229. O'Leary et al (2008) Cotinine selectively activates a subpopulation of a3/a6b2 nicotinic receptors in monkey striatum. 325 646.
See how others have used (-)-Cotinine. Click on the entry to view the PubMed entry .
PMID: # 25373622 Jacobson, GA. et al. 2014. Biomarkers. 19: 679-83.
PMID: # 25263812 Rodríguez-Álvarez, T. et al. 2014. Anal. Chem. 86: 10274-81.
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