Cortisol Antibody (4k4): sc-70875

Cortisol Antibody (4k4) is a mouse monoclonal IgG3 antibody that detects Cortisol in human samples through enzyme-linked immunosorbent assay (ELISA). Cortisol, the most potent glucocorticoid produced by the human adrenal cortex, plays a crucial role in the body′s response to stress by regulating various physiological processes. Cortisol is synthesized from cholesterol, with production stimulated by pituitary adrenocorticotropic hormone (ACTH), which is in turn regulated by corticotropin-releasing factor (CRF). The intricate balance of these hormones is vital, as high Cortisol levels inhibit ACTH and CRF secretion through a negative feedback loop, ensuring homeostasis. In the bloodstream, most Cortisol binds to corticosteroid binding globulin (CBG), also known as transcotin, which facilitates transport and bioavailability. Cortisol exerts effects by binding to specific intracellular receptors, leading to increased blood pressure and blood sugar levels while simultaneously suppressing immune responses. Understanding Cortisol dynamics and interactions is essential for comprehending stress-related disorders and developing therapeutic strategies. Anti-Cortisol antibody (4k4) serves as an invaluable tool for researchers investigating the multifaceted roles of this critical hormone in human health and disease.

The preferred Cortisol antibody is Cortisol Antibody (CORT-1): sc-51840.