COQ9 Antibody (G-4): sc-365073

COQ9 Antibody (G-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects COQ9 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). COQ9 (G-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Coenzyme Q9, also known as coenzyme Q9 homolog, is a crucial 318 amino acid protein localized in the mitochondrion, where COQ9 plays a vital role in the biosynthesis of coenzyme Q, a key component of the electron transport chain. COQ9 is essential for aerobic cellular respiration, facilitating ATP production, which is critical for energy metabolism in cells. COQ9′s importance extends beyond its metabolic role; mutations in the COQ9 gene can disrupt coenzyme Q synthesis, potentially leading to mitochondrial dysfunction and associated disorders. The COQ9 gene is located on human chromosome 16, a region that harbors over 900 genes and is linked to several genetic disorders, including giant axonal neuropathy and Rubinstein-Taybi syndrome. Understanding COQ9′s function and significance is crucial for exploring therapeutic avenues for mitochondrial diseases and other related conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

COQ9 Antibody (G-4) References:

1. Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.  |  Starkov, AA., et al. 2004. J Neurosci. 24: 7779-88. PMID: 15356189
2. Redox cycling of coenzyme Q9 as a new measure of plasma reducing power.  |  Tang, PH. and deGrauw, T. 2004. Clin Chem. 50: 1930-2. PMID: 15484328
3. COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae.  |  Johnson, A., et al. 2005. J Biol Chem. 280: 31397-404. PMID: 16027161
4. Plasma total coenzyme Q9 (CoQ9) in the New Zealand population: reference interval and biological variation.  |  Molyneux, S., et al. 2007. Clin Chem. 53: 802-3. PMID: 17405953
5. Coenzyme Q, oxidative stress and aging.  |  Sohal, RS. and Forster, MJ. 2007. Mitochondrion. 7 Suppl: S103-11. PMID: 17482528
6. Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10.  |  Lekli, I., et al. 2008. J Agric Food Chem. 56: 5331-7. PMID: 18543930
7. Determination of oxidized and reduced CoQ10 and CoQ9 in human plasma/serum using HPLC-ECD.  |  Acworth, IN., et al. 2008. Methods Mol Biol. 477: 245-58. PMID: 19082952
8. Effect of CoQ homologues on reactive oxygen generation by mitochondria.  |  Imada, I., et al. 2008. Biofactors. 32: 41-8. PMID: 19096099

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COQ9 Antibody (G-4) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-COQ9 Antibody (G-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COQ9 Antibody (G-4) Specifications

Alternate Product Name: COQ9

Product Clone Name: G-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 165-318

Epitope Target: COQ9

Epitope Species: human

Product Reactivity/Detection: COQ9

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for COQ9 Antibody (G-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin