COQ6 Antibody (H-1): sc-393932

COQ6 Antibody (H-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects COQ6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). COQ6 Antibody (H-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Coenzyme Q (CoQ), also known as ubiquinone, plays a critical role in the electron transport chain, facilitating aerobic cellular respiration within mitochondria and is vital for ATP-dependent energy production. The structure of CoQ is particularly important, as a hydrophobic isoprenoid tail anchors CoQ to the mitochondrial membrane, while a quinone head group is essential for function in the respiratory chain. The biosynthesis of CoQ involves a multi-subunit enzyme complex composed of COQ1 through COQ10, which has been extensively characterized in yeast. COQ6 encodes a flavin-dependent monooxygenase that is crucial for the biosynthesis of coenzyme Q in yeast, and in humans, COQ6 is a 468 amino acid protein whose precise function remains to be fully understood. Anti-COQ6 antibody (H-1) effectively detects this protein across different species, making anti-COQ6 antibody (H-1) an invaluable tool for researchers studying mitochondrial function and energy metabolism.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

COQ6 Antibody (H-1) References:

1. The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis.  |  Gin, P., et al. 2003. J Biol Chem. 278: 25308-16. PMID: 12721307
2. A tRNA(TRP) gene mediates the suppression of cbs2-223 previously attributed to ABC1/COQ8.  |  Hsieh, EJ., et al. 2004. Biochem Biophys Res Commun. 317: 648-53. PMID: 15063807
3. Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex.  |  Hsieh, EJ., et al. 2007. Arch Biochem Biophys. 463: 19-26. PMID: 17391640
4. Mitochondrial disorders.  |  Zeviani, M. and Carelli, V. 2007. Curr Opin Neurol. 20: 564-71. PMID: 17885446
5. Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10.  |  Lekli, I., et al. 2008. J Agric Food Chem. 56: 5331-7. PMID: 18543930
6. Biosynthesis and bioproduction of coenzyme Q10 by yeasts and other organisms.  |  Kawamukai, M. 2009. Biotechnol Appl Biochem. 53: 217-26. PMID: 19531029
7. COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness.  |  Heeringa, SF., et al. 2011. J Clin Invest. 121: 2013-24. PMID: 21540551
8. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.  |  Ben-Meir, A., et al. 2015. Aging Cell. 14: 887-95. PMID: 26111777
9. [Coenzyme Q(10) treatment for one child with COQ6 gene mutation induced nephrotic syndrome and literature review].  |  Cao, Q., et al. 2017. Zhonghua Er Ke Za Zhi. 55: 135-138. PMID: 28173653
10. COQ6 mutation in patients with nephrotic syndrome, sensorineural deafness, and optic atrophy.  |  Justine Perrin, R., et al. 2020. JIMD Rep. 54: 37-44. PMID: 32685349
11. A Family Segregating Lethal Primary Coenzyme Q10 Deficiency Due to Two Novel COQ6 Variants.  |  Wang, N., et al. 2021. Front Genet. 12: 811833. PMID: 35111204
12. COQ6 defies immune and metabolic expectations.  |  Weinberg, SE. and Chandel, NS. 2024. Nat Immunol. 25: 2170-2172. PMID: 39496955

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COQ6 Antibody (H-1) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-COQ6 Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COQ6 Antibody (H-1) Specifications

Alternate Product Name: COQ6

Product Clone Name: H-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 130-155

Epitope Target: COQ6

Epitope Species: human

Product Reactivity/Detection: COQ6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for COQ6 Antibody (H-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin