COPZ1 Antibody (B-12): sc-398081

COPZ1 Antibody (B-12) is a mouse monoclonal IgG3 kappa light chain antibody that detects COPZ1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). COPZ1 (B-12) antibody is available as the non-conjugated form. COPZ1 protein plays a crucial role in the formation of coat protein complex I (COPI) vesicles, which are essential for retrograde transport from the Golgi apparatus back to the endoplasmic reticulum (ER) and for intra-Golgi transport. This function is vital for maintaining cellular homeostasis and ensuring proper protein sorting and trafficking within the cell. COPZ1 protein is part of the heptameric coatomer complex, which is composed of two subcomplexes: one includes the COPB, COPG, COPD, and COPZ subunits, while the other consists of the COPA, b′-COP, and COPE subunits. The interaction of COPZ1 with these subunits is critical for the assembly and stability of the COPI coat, which facilitates the transport of proteins and lipids necessary for various cellular processes. Using anti-COPZ1 antibody (B-12) in research can provide insights into the mechanisms of vesicular trafficking and the implications of COPI dysfunction in various diseases.

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COPZ1 Antibody (B-12) References:

1. Impaired proteasome function rescues thermosensitivity of yeast cells lacking the coatomer subunit epsilon-COP.  |  Kimata, Y., et al. 2000. J Biol Chem. 275: 10655-60. PMID: 10744762
2. Gamma-COP appendage domain - structure and function.  |  Watson, PJ., et al. 2004. Traffic. 5: 79-88. PMID: 14690497
3. In vitro assembly and disassembly of coatomer.  |  Lowe, M. and Kreis, TE. 1995. J Biol Chem. 270: 31364-71. PMID: 8537409
4. Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval.  |  Cosson, P., et al. 1996. EMBO J. 15: 1792-8. PMID: 8617224
5. Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex.  |  Faulstich, D., et al. 1996. J Cell Biol. 135: 53-61. PMID: 8858162
6. A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer.  |  Harter, C. and Wieland, FT. 1998. Proc Natl Acad Sci U S A. 95: 11649-54. PMID: 9751720
7. Alpha-COP can discriminate between distinct, functional di-lysine signals in vitro and regulates access into retrograde transport.  |  Schröder-Köhne, S., et al. 1998. J Cell Sci. 111 (Pt 23): 3459-70. PMID: 9811561

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COPZ1 Antibody (B-12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-COPZ1 Antibody (B-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COPZ1 Antibody (B-12) Specifications

Alternate Product Name: COPZ1

Product Clone Name: B-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 128-159

Epitope Target: COPZ1

Epitope Species: human

Product Reactivity/Detection: COPZ1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for COPZ1 Antibody (B-12): P: Blocking Peptide