copine 9 Antibody (F-3): sc-376054
- copine 9 Antibody (F-3) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1-23 at the N-terminus of copine 9 of human origin
- recommended for detection of copine 9 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-copine 9 Antibody (F-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for copine 9 Antibody (F-3) for WB applications. This reagent is now offered in a bundle with copine 9 Antibody (F-3) (see ordering information below).
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Copine 9 Antibody (F-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects copine 9 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-copine 9 antibody (F-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Copine 9, also known as CPNE9, copine-9, CPN9, or COPN9, is a 503 amino acid protein that belongs to the copine family of evolutionarily conserved, soluble, calcium-dependent, membrane-binding proteins. Copine 9 plays a crucial role in signal transduction and membrane trafficking, which are essential processes for cellular communication and function. Copine 9 contains two N-terminal C2 domains and one C-terminal von Willebrand factor A (VWFA) domain, which is integral to binding phospholipids in a calcium-dependent manner. Studies in Arabidopsis thaliana show that mutants lacking copine proteins exhibit reduced cell numbers and smaller cell sizes, likely due to defects in vesicle fusion or transport, highlighting copine 9′s importance in maintaining cellular integrity and facilitating communication within and between cells.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
copine 9 Antibody (F-3) References:
- Characterization of human copine III as a phosphoprotein with associated kinase activity. | Caudell, EG., et al. 2000. Biochemistry. 39: 13034-43. PMID: 11041869
- Biochemical characterization of copine: a ubiquitous Ca2+-dependent, phospholipid-binding protein. | Tomsig, JL. and Creutz, CE. 2000. Biochemistry. 39: 16163-75. PMID: 11123945
- Copines: a ubiquitous family of Ca(2+)-dependent phospholipid-binding proteins. | Tomsig, JL. and Creutz, CE. 2002. Cell Mol Life Sci. 59: 1467-77. PMID: 12440769
- Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. | Tomsig, JL., et al. 2003. J Biol Chem. 278: 10048-54. PMID: 12522145
- Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils. | Cowland, JB., et al. 2003. J Leukoc Biol. 74: 379-88. PMID: 12949241
- The promotion of gonadal cell divisions by the Caenorhabditis elegans TRPM cation channel GON-2 is antagonized by GEM-4 copine. | Church, DL. and Lambie, EJ. 2003. Genetics. 165: 563-74. PMID: 14573470
- Multiple loci identified in a genome-wide association study of prostate cancer. | Thomas, G., et al. 2008. Nat Genet. 40: 310-5. PMID: 18264096
- The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. | Creutz, CE., et al. 1998. J Biol Chem. 273: 1393-402. PMID: 9430674
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
copine 9 Antibody (F-3) | sc-376054 | 200 µg/ml | $322.00 | |||
copine 9 Antibody (F-3): m-IgG Fc BP-HRP Bundle | sc-540502 | 200 µg Ab; 10 µg BP | $361.00 | |||
copine 9 Antibody (F-3) AC | sc-376054 AC | 500 µg/ml, 25% agarose | $424.00 | |||
copine 9 Antibody (F-3) HRP | sc-376054 HRP | 200 µg/ml | $322.00 | |||
copine 9 Antibody (F-3) FITC | sc-376054 FITC | 200 µg/ml | $336.00 | |||
copine 9 Antibody (F-3) PE | sc-376054 PE | 200 µg/ml | $349.00 | |||
copine 9 Antibody (F-3) Alexa Fluor® 488 | sc-376054 AF488 | 200 µg/ml | $364.00 | |||
copine 9 Antibody (F-3) Alexa Fluor® 546 | sc-376054 AF546 | 200 µg/ml | $364.00 | |||
copine 9 Antibody (F-3) Alexa Fluor® 594 | sc-376054 AF594 | 200 µg/ml | $364.00 | |||
copine 9 Antibody (F-3) Alexa Fluor® 647 | sc-376054 AF647 | 200 µg/ml | $364.00 | |||
copine 9 Antibody (F-3) Alexa Fluor® 680 | sc-376054 AF680 | 200 µg/ml | $364.00 | |||
copine 9 Antibody (F-3) Alexa Fluor® 790 | sc-376054 AF790 | 200 µg/ml | $364.00 | |||
copine 9 (F-3) Neutralizing Peptide | sc-376054 P | 100 µg/0.5 ml | $69.00 |