copine 1 Antibody (Z6): sc-101269

Copine 1 Antibody (Z6) is a mouse monoclonal IgG2a kappa light chain antibody that detects the copine 1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-copine 1 antibody (Z6) is available as the non-conjugated format. Copine 1, also known as CPNE1, CPN1, or COPN1, is a crucial member of the copine family of evolutionarily conserved, soluble, calcium-dependent, membrane-binding proteins, which play significant roles in signal transduction and membrane trafficking. Copine 1 is ubiquitously expressed and features a unique structure comprising two N-terminal C2 domains and one C-terminal von Willebrand factor A (VWFA) domain, also referred to as the A domain or core domain. These domains enable copine 1 to bind phospholipids in a calcium-dependent manner, facilitating membrane trafficking functions. Copine 1′s VWFA domain allows direct interaction with the ubiquitin-conjugating enzyme UBC12, suggesting involvement in the regulation of tumor necrosis factor alpha (TNFα) signaling pathways. This interaction highlights copine 1′s importance in cellular signaling processes, making copine 1 a valuable target for research in various biological contexts.

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copine 1 Antibody (Z6) References:

1. Biochemical characterization of copine: a ubiquitous Ca2+-dependent, phospholipid-binding protein.  |  Tomsig, JL. and Creutz, CE. 2000. Biochemistry. 39: 16163-75. PMID: 11123945
2. A humidity-sensitive Arabidopsis copine mutant exhibits precocious cell death and increased disease resistance.  |  Jambunathan, N., et al. 2001. Plant Cell. 13: 2225-40. PMID: 11595798
3. Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.  |  Tomsig, JL., et al. 2003. J Biol Chem. 278: 10048-54. PMID: 12522145
4. Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils.  |  Cowland, JB., et al. 2003. J Leukoc Biol. 74: 379-88. PMID: 12949241
5. Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine.  |  Tomsig, JL., et al. 2004. Biochem J. 378: 1089-94. PMID: 14674885
6. Transgenic expression of the von Willebrand A domain of the BONZAI 1/COPINE 1 protein triggers a lesion-mimic phenotype in Arabidopsis.  |  Liu, J., et al. 2005. Planta. 221: 85-94. PMID: 15843967
7. Copine A, a calcium-dependent membrane-binding protein, transiently localizes to the plasma membrane and intracellular vacuoles in Dictyostelium.  |  Damer, CK., et al. 2005. BMC Cell Biol. 6: 46. PMID: 16343335
8. The BON/CPN gene family represses cell death and promotes cell growth in Arabidopsis.  |  Yang, S., et al. 2006. Plant J. 45: 166-79. PMID: 16367962
9. The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans.  |  Creutz, CE., et al. 1998. J Biol Chem. 273: 1393-402. PMID: 9430674

The preferred copine 1/3 antibody is copine 1/3 Antibody (E-8): sc-393249.